University of Colorado School of Medicine, Aurora, Colorado.
Am J Trop Med Hyg. 2020 Jun;102(6):1189-1190. doi: 10.4269/ajtmh.20-0302.
Public health measures are needed to resolve the novel coronavirus disease (COVID-19) pandemic, although a looming economic fallout merits close attention. Early safe reintroduction of immune individuals into the workforce may be essential to protecting the economic welfare of communities. Reverse transcriptase-polymerase chain reaction testing, our primary diagnostic tool to date, has sensitivity and timing concerns, owing to sampling/handling errors, as well as a complex virus-host interaction. Reverse transcriptase-polymerase chain reaction assays do not establish immune status once the virus has been cleared. Targeted serosurveillance for the determination of individuals' potential for transmissibility, particularly if paired with direct pathogen testing, may aid in "cleared for business" decision-making.
需要采取公共卫生措施来解决新型冠状病毒病（COVID-19）大流行，尽管迫在眉睫的经济后果值得密切关注。尽早将免疫个体安全地重新引入劳动力队伍对于保护社区的经济福利可能至关重要。逆转录酶-聚合酶链反应检测是我们迄今为止的主要诊断工具，但由于采样/处理错误以及复杂的病毒-宿主相互作用，存在敏感性和时间问题。一旦清除病毒，逆转录酶-聚合酶链反应检测就无法确定免疫状态。针对个体传播潜力的靶向血清学监测，特别是与直接病原体检测相结合，可能有助于“可营业”决策。
