Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Allergy. 2020 Jul;75(7):1699-1709. doi: 10.1111/all.14289. Epub 2020 Apr 6.
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has recently spread worldwide and been declared a pandemic. We aim to describe here the various clinical presentations of this disease by examining eleven cases.
Electronic medical records of 11 patients with COVID-19 were collected, and demographics, clinical manifestations, outcomes, key laboratory results, and radiological images are discussed.
The clinical course of the eleven cases demonstrated the complexity of the COVID-19 profile with different clinical presentations. Clinical manifestations range from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Laboratory detection of the viral nucleic acid can yield false-negative results, and serological testing of virus-specific IgG and IgM antibodies should be used as an alternative for diagnosis. Patients with common allergic diseases did not develop distinct symptoms and severe courses. Cases with a pre-existing condition of chronic obstructive pulmonary disease or complicated with a secondary bacterial pneumonia were more severe.
All different clinical characteristics of COVID-19 should be taken into consideration to identify patients that need to be in strict quarantine for the efficient containment of the pandemic.
由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起的 2019 年冠状病毒病（COVID-19）疫情最近在全球范围内爆发，并已宣布为大流行。我们旨在通过检查 11 例来描述这种疾病的各种临床表现。
收集了 11 例 COVID-19 患者的电子病历，并讨论了人口统计学、临床表现、结局、关键实验室结果和影像学图像。
11 例患者的临床过程表明 COVID-19 具有不同临床表现的复杂性。临床表现从无症状病例到轻度和重度症状病例不等，伴有或不伴有肺炎。病毒核酸的实验室检测可能会产生假阴性结果，应使用病毒特异性 IgG 和 IgM 抗体的血清学检测作为替代诊断。患有常见过敏性疾病的患者没有出现明显的症状和严重的病程。患有慢性阻塞性肺疾病的既往病史或合并继发性细菌性肺炎的患者病情更严重。
应考虑 COVID-19 的所有不同临床特征，以识别需要严格隔离的患者，从而有效控制疫情。
