Goit Bharat Kumar, Khattri Jai Bahadur
Department of Psychiatry, Janaki Medical College, Janakpur, Nepal.
Department of Psychiatry, Manipal College of Medical Sciences, Pokhara, Nepal.
JNMA J Nepal Med Assoc. 2019 Sep-Oct;57(219):331-334. doi: 10.31729/jnma.4642.
Schizophrenia is a mental disorder in which clear consciousness and the intellectual capacity are usually maintained, although certain cognitive deficits may evolve in the course of illness. Working memory impairment in schizophrenia affects the course, outcome, and quality of life of the patient significantly. The aim of the study was to find out the prevalence of working memory impairment in drug naive schizophrenic patients.
This descriptive cross-sectional study was done in a tertiary care hospital, from June 2015 to December 2015 after taking ethical clearance from institutional review board registration number 38970/062/063. Convenience sampling was done. The samples of 30 schizophrenic patients between the ages of 15 to 45 years were enrolled from the inpatient and outpatient unit of department according to inclusion and exclusion criteria. Data was collected and entry was done in Epi Info, point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.
The prevalence of working memory impairment was 26 (86.7%) in digit span forward test and 27 (90%) in digit span backward test. The mean age of patients was 27.5 years and the age of onset of schizophrenia was mainly in the age group between 16 to 25 years 16 (53.3%).
These finding suggests high prevalence of working memory impairment in schizophrenic patients.
精神分裂症是一种精神障碍，尽管在疾病过程中可能会出现某些认知缺陷，但通常意识清晰且智力能力保持正常。精神分裂症患者的工作记忆损害对患者的病程、预后和生活质量有显著影响。本研究的目的是了解未使用过药物的精神分裂症患者中工作记忆损害的患病率。
这项描述性横断面研究于2015年6月至2015年12月在一家三级护理医院进行，此前已获得机构审查委员会伦理批准，注册号为38970/062/063。采用方便抽样。根据纳入和排除标准，从该科室的住院部和门诊部招募了30名年龄在15至45岁之间的精神分裂症患者样本。收集数据并录入Epi Info，计算95%置信区间的点估计值以及二元数据的频率和比例。
数字广度顺背测验中工作记忆损害的患病率为26例（86.7%），数字广度倒背测验中为27例（90%）。患者的平均年龄为27.5岁，精神分裂症的发病年龄主要在16至25岁年龄组，共16例（53.3%）。
这些发现表明精神分裂症患者中工作记忆损害的患病率较高。
