Department of Pediatrics, Washington University School of Medicine , St. Louis, MO, USA.
Department of Cell Biology & Physiology, Washington University School of Medicine , St. Louis, MO, USA.
Gut Microbes. 2020 Sep 2;11(5):1475-1482. doi: 10.1080/19490976.2020.1750273. Epub 2020 Apr 24.
Trehalose is a disaccharide and fasting-mimetic that has been both canonized and vilified for its putative cardiometabolic and microbial effects. Trehalose analogues are currently under development to extend the key metabolic therapeutic actions of trehalose without adversely affecting host microbial communities. In the current study, we contrast the extent to which trehalose and its degradation-resistant analogue, lactotrehalose (LT), modulate microbial communities and host transcriptomic profiles. We demonstrate that trehalose and LT each exert adaptive metabolic and microbial effects that both overlap and diverge. We postulate that these effects depend both upon compound stability and bioavailability, and on stereospecific signal transduction. In context, the data suggest that trehalose is unlikely to be harmful, and yet it harbors unique effects that are not yet fully replicated by its analogues. These compounds are thus valuable probes to better define trehalose structure-function, and to offer as therapeutic metabolic agents.
海藻糖是一种二糖，也是一种模拟禁食的物质，因其可能对心血管代谢和微生物产生的影响而备受推崇和诋毁。目前正在开发海藻糖类似物，以扩展海藻糖的关键代谢治疗作用，而不会对宿主微生物群落产生不利影响。在本研究中，我们对比了海藻糖及其抗降解类似物乳海藻糖（LT）调节微生物群落和宿主转录组谱的程度。我们证明，海藻糖和 LT 各自发挥适应性代谢和微生物作用，这些作用既重叠又有差异。我们推测，这些作用既取决于化合物的稳定性和生物利用度，也取决于立体特异性信号转导。从上下文来看，这些数据表明海藻糖不太可能有害，但它具有独特的作用，目前还没有被其类似物完全复制。因此，这些化合物是更好地定义海藻糖结构-功能的有价值的探针，并可作为治疗代谢剂。
