Recent developments of small molecules targeting RNA mA modulators.

N-methyladenosine (mA) is the most abundant internal post-transcriptional modification in eukaryotic mRNA. The development of emerging technologies such as mA-seq, has helped reveal the fundamental role of mA-RNA in regulation of the mammalian transcriptome. With the identification and advances in the understanding of mA modulators, the relationship between mA and human diseases is gradually being revealed. This review summarizes recent progress in the understanding of the role of mA modulators in human disease and their structural characteristics. We highlight the potential of small-molecule regulators targeting mA associated proteins as tool molecules and disease treatment options from the medicinal chemistry perspective.