DeWitt Daughtry Family Department of Surgery, Division of Oral and Maxillofacial Surgery, Section of Head and Neck Surgical Oncology/, Microvascular Reconstructive Surgery, University of Miami, Miller School of Medicine/Jackson Health System, Deering Medical Plaza, 9380 SW 150(th) St #170, Miami, FL 33176, United States.
Fellow Head and Neck Oncology, Microvascular Surgery, Department of Oral and Maxillofacial Surgery, University of Michigan, 2229 S State st unit 112, Ann Arbor, MI 48104, United States.
Oral Oncol. 2020 Oct;109:104691. doi: 10.1016/j.oraloncology.2020.104691. Epub 2020 Apr 21.
The presence of synchronous benign and malignant salivary gland neoplasms is very rare. The authors present a previously unreported combination of Secretory Carcinoma (SC) and Warthin's Tumor (WT) within the same parotid gland.
The patient presented with increasingly painful enlargement of the left parotid gland. CT scan with contrast revealed a heterogeneous solid/cystic mass in the superficial lobe. Fine needle aspiration cytology favored pleomorphic adenoma (PA) and patient underwent superficial parotidectomy without complication.
Final pathology revealed concomitant presence of SC and WT. Stains were positive for S100 and mammaglobin, and FISH revealed the presence of t(12;15) (p13;q25) translocation, resulting in the ETV6-NTRK3 fusion gene.
It is important for surgeons and pathologists to note the potential for co-existing benign and malignant pathology within the same salivary gland, as this can have an impact on management and prognosis for patients.
同时存在良性和恶性涎腺肿瘤非常罕见。作者报告了一例在同一腮腺内同时存在分泌性癌（SC）和沃辛瘤（WT）的病例，这种组合此前尚未报道。
患者表现为左侧腮腺逐渐增大伴疼痛。增强 CT 扫描显示浅叶内混杂实性/囊性肿块。细针穿刺细胞学检查倾向于多形性腺瘤（PA），患者行腮腺浅叶切除术，无并发症。
最终病理显示同时存在 SC 和 WT。免疫组化染色 S100 和 mammaglobin 阳性，FISH 显示存在 t(12;15)（p13;q25）易位，导致 ETV6-NTRK3 融合基因。
外科医生和病理学家注意到同一涎腺内可能存在良性和恶性并存的病理非常重要，因为这会影响患者的管理和预后。
