同侧腮腺内同时存在分泌性癌和沃辛瘤。

Concurrent presence of secretory carcinoma and Warthin's tumor in ipsilateral parotid gland.

机构信息

DeWitt Daughtry Family Department of Surgery, Division of Oral and Maxillofacial Surgery, Section of Head and Neck Surgical Oncology/, Microvascular Reconstructive Surgery, University of Miami, Miller School of Medicine/Jackson Health System, Deering Medical Plaza, 9380 SW 150(th) St #170, Miami, FL 33176, United States.

Fellow Head and Neck Oncology, Microvascular Surgery, Department of Oral and Maxillofacial Surgery, University of Michigan, 2229 S State st unit 112, Ann Arbor, MI 48104, United States.

出版信息

Oral Oncol. 2020 Oct;109:104691. doi: 10.1016/j.oraloncology.2020.104691. Epub 2020 Apr 21.

DOI:10.1016/j.oraloncology.2020.104691

PMID:32331963

Abstract

BACKGROUND

The presence of synchronous benign and malignant salivary gland neoplasms is very rare. The authors present a previously unreported combination of Secretory Carcinoma (SC) and Warthin's Tumor (WT) within the same parotid gland.

METHODS

The patient presented with increasingly painful enlargement of the left parotid gland. CT scan with contrast revealed a heterogeneous solid/cystic mass in the superficial lobe. Fine needle aspiration cytology favored pleomorphic adenoma (PA) and patient underwent superficial parotidectomy without complication.

RESULTS

Final pathology revealed concomitant presence of SC and WT. Stains were positive for S100 and mammaglobin, and FISH revealed the presence of t(12;15) (p13;q25) translocation, resulting in the ETV6-NTRK3 fusion gene.

CONCLUSION

It is important for surgeons and pathologists to note the potential for co-existing benign and malignant pathology within the same salivary gland, as this can have an impact on management and prognosis for patients.

摘要