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Response to the editorial "COVID-19 in patients with cardiovascular diseases": Covid-19 treatment with hydroxychloroquine or chloroquine and azithromycin: A potential risk of Torsades de Pointes.对社论《心血管疾病患者的COVID-19》的回应：使用羟氯喹或氯喹及阿奇霉素治疗COVID-19：尖端扭转型室速的潜在风险。
Arch Cardiovasc Dis. 2020 May;113(5):367-368. doi: 10.1016/j.acvd.2020.04.001. Epub 2020 Apr 15.
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Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection.氯喹、羟氯喹和阿奇霉素对 SARS-CoV-2 感染患者校正 QT 间期的影响。
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Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19).COVID-19 住院患者使用羟氯喹（无论是否联合使用阿奇霉素）导致 QT 间期延长的风险。
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Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine.与阿奇霉素联合或不联合氯喹或羟氯喹相关的QT间期延长或尖端扭转型室速的安全信号。
Res Social Adm Pharm. 2021 Feb;17(2):483-486. doi: 10.1016/j.sapharm.2020.04.016. Epub 2020 Apr 19.
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Insights on the Evidence of Cardiotoxicity of Hydroxychloroquine Prior and During COVID-19 Epidemic.羟氯喹在 COVID-19 流行前和流行期间致心脏毒性的证据分析。
Clin Transl Sci. 2021 Jan;14(1):163-169. doi: 10.1111/cts.12883. Epub 2020 Oct 23.
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Site mapping and small molecule blind docking reveal a possible target site on the SARS-CoV-2 main protease dimer interface.基于配体的虚拟筛选和小分子盲对接揭示了 SARS-CoV-2 主蛋白酶二聚体界面上的一个可能的靶位。
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Cardiovascular Toxicities Associated With Hydroxychloroquine and Azithromycin: An Analysis of the World Health Organization Pharmacovigilance Database.羟氯喹啉和阿奇霉素相关的心血管毒性：世界卫生组织药物警戒数据库分析
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10
"Off-label" use of hydroxychloroquine, azithromycin, lopinavir-ritonavir and chloroquine in COVID-19: A survey of cardiac adverse drug reactions by the French Network of Pharmacovigilance Centers.羟氯喹、阿奇霉素、洛匹那韦-利托那韦和氯喹在 COVID-19 中的“超适应证”使用：法国药物警戒中心网络对心脏不良药物反应的调查。
Therapie. 2020 Jul-Aug;75(4):371-379. doi: 10.1016/j.therap.2020.05.002. Epub 2020 May 7.

本文引用的文献

1
COVID-19 in patients with cardiovascular diseases.心血管疾病患者中的新型冠状病毒肺炎
Arch Cardiovasc Dis. 2020 Apr;113(4):225-226. doi: 10.1016/j.acvd.2020.03.009. Epub 2020 Mar 31.
2
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.中国武汉成人 COVID-19 住院患者的临床病程和死亡危险因素：一项回顾性队列研究。
Lancet. 2020 Mar 28;395(10229):1054-1062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11.
3
Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.白细胞介素-6 抑制 hERG 是心脏和全身炎症中获得性长 QT 风险的基础。
PLoS One. 2018 Dec 6;13(12):e0208321. doi: 10.1371/journal.pone.0208321. eCollection 2018.
4
Assessment of Multi-Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study.评估多离子通道阻滞：I 期随机研究设计的结果：CiPA I 期心电图生物标志物验证研究。
Clin Pharmacol Ther. 2019 Apr;105(4):943-953. doi: 10.1002/cpt.1303. Epub 2019 Jan 18.
5
Azithromycin Causes a Novel Proarrhythmic Syndrome.阿奇霉素会引发一种新型的心律失常综合征。
Circ Arrhythm Electrophysiol. 2017 Apr;10(4). doi: 10.1161/CIRCEP.115.003560.
6
Assessment of temperature-induced hERG channel blockade variation by drugs.药物对温度诱导的人乙醚相关基因（hERG）通道阻滞变化的评估。
J Appl Toxicol. 2015 Jul;35(7):799-805. doi: 10.1002/jat.3074. Epub 2014 Oct 28.
7
In vitro cardiovascular effects of dihydroartemisin-piperaquine combination compared with other antimalarials.二氢青蒿素-哌喹复方制剂与其他抗疟药的体外心血管效应比较。
Antimicrob Agents Chemother. 2012 Jun;56(6):3261-70. doi: 10.1128/AAC.05688-11. Epub 2012 Mar 5.
8
Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.长期使用羟氯喹与QT间期延长及难治性室性心律失常相关。
Clin Toxicol (Phila). 2006;44(2):173-5. doi: 10.1080/15563650500514558.

Response to the editorial "COVID-19 in patients with cardiovascular diseases": Covid-19 treatment with hydroxychloroquine or chloroquine and azithromycin: A potential risk of Torsades de Pointes.

作者信息

Funck-Brentano Christian, Salem Joe-Elie, Nguyen Lee S, Drici Milou-Daniel, Roden Dan M

机构信息

Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, INSERM, CIC Paris-Est (CIC-1901), Department of Pharmacology, 75013 Paris, France.

Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, INSERM, CIC Paris-Est (CIC-1901), Department of Pharmacology, 75013 Paris, France.

出版信息

Arch Cardiovasc Dis. 2020 May;113(5):367-368. doi: 10.1016/j.acvd.2020.04.001. Epub 2020 Apr 15.

DOI:10.1016/j.acvd.2020.04.001
PMID:32331979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7158843/
Abstract
摘要