Lawrence Elizabeth J, Zanic Marija, Rice Luke M
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA
J Cell Sci. 2020 Apr 24;133(8):jcs243097. doi: 10.1242/jcs.243097.
CLIP-associating proteins (CLASPs) form an evolutionarily conserved family of regulatory factors that control microtubule dynamics and the organization of microtubule networks. The importance of CLASP activity has been appreciated for some time, but until recently our understanding of the underlying molecular mechanisms remained basic. Over the past few years, studies of, for example, migrating cells, neuronal development, and microtubule reorganization in plants, along with reconstitutions, have provided new insights into the cellular roles and molecular basis of CLASP activity. In this Cell Science at a Glance article and the accompanying poster, we will summarize some of these recent advances, emphasizing how they impact our current understanding of CLASP-mediated microtubule regulation.
CLIP相关蛋白（CLASPs）构成了一个进化上保守的调节因子家族，其控制微管动力学和微管网络的组织。一段时间以来，人们已经认识到CLASP活性的重要性，但直到最近，我们对其潜在分子机制的理解仍停留在基础层面。在过去几年中，例如对迁移细胞、神经元发育以及植物微管重组的研究，再加上重组实验，为CLASP活性的细胞作用和分子基础提供了新的见解。在这篇“细胞科学一览”文章及随附的海报中，我们将总结其中一些最新进展，重点强调它们如何影响我们目前对CLASP介导的微管调节的理解。
