Steinhorn S C, Ries L G
Demographic Analysis Section/NCI, Bethesda, MD 20892.
Biomed Pharmacother. 1988;42(10):675-81.
Statistically significant increases in 3- and 5-year survival rates were observed for white children under 15 years of age diagnosed with acute lymphocytic leukemia (ALL) from 1973-1976 to 1977-1980 in 9 geographic areas of the United States. Survival for the cohort diagnosed in 1977-1980 was 78% at 3 years, 68% at 5 years, and 42% at 10 years from diagnosis. For the cohort diagnosed in 1981-1984, however, slight but not significant decreases in survival rates were seen. Improvements in 3- and 5-year survival for children with acute granulocytic leukemia (AGL) were found between the cohort diagnosed in 1973-1976 as compared to 1977-1980, but these rates stabilized as well in the 1980s. While the age-adjusted incidence rate for all childhood leukemias fluctuated slightly between 1973 and 1985, age-adjusted mortality continued to decline, dropping from 2.5 per 100,000 white population under 15 years of age in 1973 to 1.4 per 100,000 in 1985, an average annual decrease of approximately 4%.
在美国9个地理区域，1973 - 1976年至1977 - 1980年期间被诊断为急性淋巴细胞白血病（ALL）的15岁以下白人儿童，其3年和5年生存率有统计学意义的显著提高。1977 - 1980年确诊队列的3年生存率为78%，5年生存率为68%，确诊后10年生存率为42%。然而，对于1981 - 1984年确诊的队列，生存率略有下降，但不显著。与1973 - 1976年确诊的急性粒细胞白血病（AGL）儿童队列相比，1977 - 1980年确诊队列的3年和5年生存率有所提高，但这些生存率在20世纪80年代也趋于稳定。虽然1973年至1985年期间所有儿童白血病的年龄调整发病率略有波动，但年龄调整死亡率持续下降，从1973年每10万名15岁以下白人人口中的2.5例降至1985年的1.4例，年均下降约4%。
