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Commentary - Do the negative results of the PENUT trial close the book on erythropoietin for premature infant brain?评论——PENUT试验的阴性结果是否为促红细胞生成素用于早产儿脑部研究画上了句号？
J Neonatal Perinatal Med. 2020;13(2):149-152. doi: 10.3233/NPM-200444.
2
Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age.早产儿早期给予高剂量促红细胞生成素与胎龄相当足月时脑 MRI 异常的相关性研究。
JAMA. 2014 Aug 27;312(8):817-24. doi: 10.1001/jama.2014.9645.
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Erythropoietin to prevent and treat the anemia of prematurity.促红细胞生成素用于预防和治疗早产儿贫血。
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Use of epoetin (erythropoietin) in the anemia of prematurity.促红细胞生成素在早产儿贫血中的应用。
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J Paediatr Child Health. 1994 Aug;30(4):293-5. doi: 10.1111/j.1440-1754.1994.tb00647.x.
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Erythropoietin in anemia of prematurity.促红细胞生成素与早产儿贫血
J Matern Fetal Neonatal Med. 2012 Oct;25(Suppl 5):80-4. doi: 10.3109/14767058.2012.716987.

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Early High-Dose Erythropoietin and Cognitive Functions of School-Aged Children Born Very Preterm.早期高剂量促红细胞生成素与极早早产儿童学龄期认知功能的关系。
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Role of Microglial Modulation in Therapies for Perinatal Brain Injuries Leading to Neurodevelopmental Disorders.小胶质细胞调节在治疗围产期脑损伤导致神经发育障碍中的作用。
Adv Neurobiol. 2024;37:591-606. doi: 10.1007/978-3-031-55529-9_33.
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Beyond brain injury biomarkers: chemoattractants and circulating progenitor cells as biomarkers of endogenous rehabilitation effort in preterm neonates with encephalopathy.超越脑损伤生物标志物：趋化因子和循环祖细胞作为患有脑病的早产儿内源性康复努力的生物标志物
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本文引用的文献

1
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.早产儿红细胞生成素神经保护的随机试验。
N Engl J Med. 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423.
2
Microglia: Newly discovered complexity could lead to targeted therapy for neonatal white matter injury and dysmaturation.小胶质细胞：新发现的复杂性可能会带来针对新生儿白质损伤和发育异常的靶向治疗。
J Neonatal Perinatal Med. 2019;12(3):239-242. doi: 10.3233/NPM-190303.
3
Dysmaturation of Premature Brain: Importance, Cellular Mechanisms, and Potential Interventions.早产儿脑发育不良：重要性、细胞机制及潜在干预措施。
Pediatr Neurol. 2019 Jun;95:42-66. doi: 10.1016/j.pediatrneurol.2019.02.016. Epub 2019 Feb 27.
4
Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis.预防性早期使用促红细胞生成素对早产儿的神经保护作用：一项荟萃分析。
Pediatrics. 2017 May;139(5). doi: 10.1542/peds.2016-4317. Epub 2017 Apr 7.
5
White matter injury in the preterm infant: pathology and mechanisms.早产儿脑白质损伤：病理与机制
Acta Neuropathol. 2017 Sep;134(3):331-349. doi: 10.1007/s00401-017-1718-6. Epub 2017 May 22.
6
Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage.在脑室周围白质损伤新生大鼠模型中，重组人促红细胞生成素通过诱导内源性促红细胞生成素受体和神经球蛋白发挥神经保护作用。
Neurosci Lett. 2017 May 22;650:12-17. doi: 10.1016/j.neulet.2017.03.024. Epub 2017 Mar 27.
7
Developmental Assessments in Preterm Children: A Meta-analysis.早产儿发育评估：荟萃分析。
Pediatrics. 2016 Aug;138(2). doi: 10.1542/peds.2016-0251.
8
Preschool Assessment of Preterm Infants Treated With Darbepoetin and Erythropoietin.用达贝泊汀和促红细胞生成素治疗的早产儿的学前评估
Pediatrics. 2016 Mar;137(3):e20153859. doi: 10.1542/peds.2015-3859. Epub 2016 Feb 15.
9
Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants.基于束流的空间统计学评估早期促红细胞生成素对早产儿脑白质发育的神经保护作用。
Brain. 2015 Feb;138(Pt 2):388-97. doi: 10.1093/brain/awu363. Epub 2014 Dec 22.
10
Erythropoietin: emerging role of erythropoietin in neonatal neuroprotection.促红细胞生成素：促红细胞生成素在新生儿神经保护中的新作用。
Pediatr Neurol. 2014 Oct;51(4):481-8. doi: 10.1016/j.pediatrneurol.2014.06.008. Epub 2014 Jun 24.

Commentary - Do the negative results of the PENUT trial close the book on erythropoietin for premature infant brain?

作者信息

Volpe Joseph J

机构信息

Department of Neurology, Harvard Medical School, Boston, MA, USA.

Department of Pediatric Newborn Medicine, Harvard Medical School, Boston, MA, USA.

出版信息

J Neonatal Perinatal Med. 2020;13(2):149-152. doi: 10.3233/NPM-200444.

DOI:10.3233/NPM-200444
PMID:32333558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7369037/
Abstract
摘要