Commentary - Do the negative results of the PENUT trial close the book on erythropoietin for premature infant brain?
作者信息
Volpe Joseph J
机构信息
Department of Neurology, Harvard Medical School, Boston, MA, USA.
Department of Pediatric Newborn Medicine, Harvard Medical School, Boston, MA, USA.
出版信息
J Neonatal Perinatal Med. 2020;13(2):149-152. doi: 10.3233/NPM-200444.
Abstract
摘要
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Commentary - Do the negative results of the PENUT trial close the book on erythropoietin for premature infant brain?评论——PENUT试验的阴性结果是否为促红细胞生成素用于早产儿脑部研究画上了句号？
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本文引用的文献
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A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.早产儿红细胞生成素神经保护的随机试验。
N Engl J Med. 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423.
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Microglia: Newly discovered complexity could lead to targeted therapy for neonatal white matter injury and dysmaturation.小胶质细胞：新发现的复杂性可能会带来针对新生儿白质损伤和发育异常的靶向治疗。
J Neonatal Perinatal Med. 2019;12(3):239-242. doi: 10.3233/NPM-190303.
3
Dysmaturation of Premature Brain: Importance, Cellular Mechanisms, and Potential Interventions.早产儿脑发育不良：重要性、细胞机制及潜在干预措施。
Pediatr Neurol. 2019 Jun;95:42-66. doi: 10.1016/j.pediatrneurol.2019.02.016. Epub 2019 Feb 27.
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Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis.预防性早期使用促红细胞生成素对早产儿的神经保护作用：一项荟萃分析。
Pediatrics. 2017 May;139(5). doi: 10.1542/peds.2016-4317. Epub 2017 Apr 7.
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White matter injury in the preterm infant: pathology and mechanisms.早产儿脑白质损伤：病理与机制
Acta Neuropathol. 2017 Sep;134(3):331-349. doi: 10.1007/s00401-017-1718-6. Epub 2017 May 22.
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Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage.在脑室周围白质损伤新生大鼠模型中，重组人促红细胞生成素通过诱导内源性促红细胞生成素受体和神经球蛋白发挥神经保护作用。
Neurosci Lett. 2017 May 22;650:12-17. doi: 10.1016/j.neulet.2017.03.024. Epub 2017 Mar 27.
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