基于 miRNA 生物标志物系统发育分析的抑郁与胃食管反流的相关性。

The Association between Depression and Gastroesophageal Reflux based on Phylogenetic Analysis of miRNA Biomarkers.

机构信息

Institute of Statistical Science, Academia Sinica, Nankang, Taipei, Taiwan.

Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan.

出版信息

Curr Med Chem. 2020;27(38):6536-6547. doi: 10.2174/0929867327666200425214906.

DOI:10.2174/0929867327666200425214906

PMID:32334497

Abstract

A number of clinical studies have revealed that there is an association between major depression (MD) and gastroesophageal reflux disease (GERD). Both the diseases are shown to affect a large proportion of the global population. More advanced studies for understanding the comorbidity mechanism of these two diseases can shed light on developing new therapies of both diseases. To the best of our knowledge, there has not been any research work in the literature investigating the relationship between MD and GERD using their miRNA biomarkers. We adopt a phylogenetic analysis to analyze their miRNA biomarkers. From our analyzed results, the association between these two diseases can be explored through miRNA phylogeny. In addition to evidence from the phylogenetic analysis, we also demonstrate epidemiological evidence for the relationship between MD and GERD based on Taiwan biobank data.

摘要

许多临床研究表明，重度抑郁症（MD）和胃食管反流病（GERD）之间存在关联。这两种疾病都表明在全球范围内有很大一部分人群受到影响。更深入的研究可以了解这两种疾病的共病机制，为两种疾病的新疗法的开发提供思路。据我们所知，目前还没有任何研究工作使用 miRNA 生物标志物来研究 MD 和 GERD 之间的关系。我们采用系统发育分析来分析它们的 miRNA 生物标志物。从我们的分析结果可以看出，通过 miRNA 系统发育可以探索这两种疾病之间的关联。除了系统发育分析的证据外，我们还基于台湾生物银行数据提供了 MD 和 GERD 之间关系的流行病学证据。