Institute of Statistical Science, Academia Sinica, Nankang, Taipei, Taiwan.
Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan.
Curr Med Chem. 2021;28(27):5648-5656. doi: 10.2174/0929867327666201117100026.
An association between migraine and Major Depression (MD) has been revealed in a number of clinical studies. Both diseases have affected a large global population. More understanding of the comorbidity mechanism of these two diseases can shed light on developing new therapies for their treatment.
To the best of our knowledge, there have not been any researches in the literature based on microRNA (miRNA) biomarkers to investigate the relationship between MD and migraine. In this study, we have discussed the association between these two diseases based on their miRNA biomarkers. In addition to miRNA biomarkers, we have also demonstrated epidemiological evidence for their association based on Taiwan Biobank (TWB) data.
Among the 12 migraine miRNA biomarkers, 11 are related to MD. Only miR-181a has no direct evidence to be involved in the mechanism of MD. In addition to the biological biomarker evidence, the statistical analysis using the large-scale epidemiologic data collected from TWB provides strong evidence on the relationship between MD and migraine.
The evidence based on both molecular and epidemiological data reveals the significant association between MD and migraine. This result can help investigate the correlated underlying mechanism of these two diseases.
许多临床研究表明偏头痛与重度抑郁症（MD）之间存在关联。这两种疾病都影响了全球很大一部分人群。更多地了解这两种疾病的共病机制可以为它们的治疗开发新的疗法提供启示。
据我们所知，目前还没有基于 microRNA（miRNA）生物标志物的研究来探讨 MD 和偏头痛之间的关系。在这项研究中，我们根据它们的 miRNA 生物标志物讨论了这两种疾病之间的关联。除了 miRNA 生物标志物，我们还基于台湾生物银行（TWB）的数据展示了它们关联的流行病学证据。
在 12 个偏头痛 miRNA 生物标志物中，有 11 个与 MD 相关。只有 miR-181a 没有直接证据表明它参与 MD 的发病机制。除了基于生物标志物的证据外，使用 TWB 收集的大规模流行病学数据进行的统计分析为 MD 和偏头痛之间的关系提供了强有力的证据。
基于分子和流行病学数据的证据揭示了 MD 和偏头痛之间的显著关联。这一结果有助于研究这两种疾病相关的潜在机制。
