Specialist Orthodontist, Dubai, United Arab Emirates; formerly Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
BMC Oral Health. 2020 Apr 25;20(1):126. doi: 10.1186/s12903-020-01109-3.
Treatment with fixed orthodontic appliances has been associated with significant biofilm accumulation, thus putting patients at a higher risk of oral health deterioration. The use of probiotics has been proposed to be useful in the prevention or treatment of oral pathologies such as caries and diseases of periodontal tissues. Our aim was to investigate the effects of probiotic use on inflammation of the gingival tissues and the decalcification of the enamel in patients being treated with fixed orthodontic appliances.
We searched without restrictions 8 databases and performed hand searching until September 2019. We searched for randomized controlled trials (RCTs) evaluating whether individuals with fixed orthodontic appliances benefit from probiotic treatment in terms of the inflammation of the gingivae and decalcification of the enamel. Following the selection of studies and the extraction of pertinent data, we appraised the risk of bias and the confidence in the observed effects based on established methodologies.
From the final qualifying studies, three did not show any statistically significant effect on gingival inflammation after probiotic administration of up to 1 month. Similarly, non-significant differences were noted in another study regarding white spot lesions development (mean administration for 17 months). No adverse effects were reported and the level of evidence was considered moderate.
Supplementation of orthodontic patients with probiotics did not affect the development of inflammation in the gingivae and decalcification in the enamel. Additional RCTs, with longer intervention and follow-up periods, and involving different combinations of probiotic strains are required.
PROSPERO (CRD42018118008).
固定正畸矫治器的治疗与生物膜的大量积累有关，因此使患者的口腔健康恶化的风险更高。已经提出使用益生菌在预防或治疗龋齿和牙周组织疾病等口腔疾病方面是有用的。我们的目的是研究益生菌的使用对接受固定正畸矫治器治疗的患者的牙龈组织炎症和牙釉质脱矿的影响。
我们无限制地搜索了 8 个数据库，并进行了手工搜索，直到 2019 年 9 月。我们搜索了随机对照试验（RCT），评估了接受固定正畸矫治器的个体是否受益于益生菌治疗，以评估牙龈炎症和牙釉质脱矿的情况。在选择研究和提取相关数据后，我们根据既定方法评估了偏倚风险和观察到的效果的置信度。
从最终合格的研究中，有三项研究在给予益生菌后长达 1 个月的时间内对牙龈炎症没有任何统计学上的显著影响。同样，在另一项关于白斑病变发展的研究中（平均给药 17 个月）也未发现任何显著差异。没有报告不良反应，证据水平被认为是中等的。
给正畸患者补充益生菌不会影响牙龈炎症的发展和牙釉质脱矿。需要更多的 RCT，干预和随访时间更长，并涉及不同的益生菌菌株组合。
PROSPERO（CRD42018118008）。
