Department of Career Development, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
Department of Career Development, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
Enferm Infecc Microbiol Clin (Engl Ed). 2021 Jan;39(1):14-21. doi: 10.1016/j.eimc.2020.02.029. Epub 2020 Apr 22.
Viral hepatitis infection is associated with negative impacts on renal function that may lead to nephropathy. We investigated associations between chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) and/or end-stage renal disease (ESRD) in a large, representative sample from a nationwide U.S.
This population-based, retrospective observational study extracted data from the U.S. Nationwide Inpatient Sample (NIS) database, including adults ≥18 years old admitted to U.S. hospitals between 2005 and 2014 with records of chronic HBV infection in medical history. The final analytic sample included 70,674 HBV-infected patients and 282,696 matched non-HBV controls. Study endpoints were prevalent CKD and ESRD. Associations between CKD/ESRD and HBV and patients' clinical characteristics were determined by logistic regression analysis.
HBV infection was associated with slightly increased risk of prevalent CKD (OR: 1.06, 95% CI: 1.004-1.119) and an approximate 2-times risk of prevalent ESRD (OR: 1.98, 95% CI: 1.880-2.086). HBV infection in both genders was associated with slightly increased risk of CKD (males, OR: 1.09, 95% CI: 1.02-1.16; females, OR: 1.07, 95% CI: 0.98,1.17), and significantly associated with increased risk for CKD among non-diabetic patients (OR: 1.23, 95% CI: 1.15-1.32), white patients (OR: 1.14, 95% CI: 1.06-1.23) and Asian/Pacific Islanders (OR: 1.13, 95% CI: 0.98-1.30).
Chronic HBV infection is associated with slightly increased risk for CKD and greater risk for ESRD in males and females, Whites and Asian/Pacific Islanders and non-diabetic patients.
病毒肝炎感染与肾功能下降相关，可能导致肾病。我们在美国全国范围内的大型代表性样本中调查了慢性乙型肝炎病毒（HBV）感染与慢性肾病（CKD）和/或终末期肾病（ESRD）之间的关联。
这项基于人群的回顾性观察性研究从美国全国住院患者样本（NIS）数据库中提取数据，包括 2005 年至 2014 年间在美国医院住院的年龄≥18 岁的成人，其病史中记录有慢性 HBV 感染。最终分析样本包括 70674 例 HBV 感染患者和 282696 例匹配的非 HBV 对照。CKD 和 ESRD 的发生率是研究终点。通过逻辑回归分析确定了 CKD/ESRD 与 HBV 之间的关联以及患者的临床特征。
HBV 感染与 CKD 发生率略有增加相关（OR：1.06，95%CI：1.004-1.119），与 ESRD 发生率增加约 2 倍相关（OR：1.98，95%CI：1.880-2.086）。HBV 感染在男性和女性中均与 CKD 风险略有增加相关（男性，OR：1.09，95%CI：1.02-1.16；女性，OR：1.07，95%CI：0.98，1.17），并且与非糖尿病患者的 CKD 风险显著相关（OR：1.23，95%CI：1.15-1.32），白人患者（OR：1.14，95%CI：1.06-1.23）和亚裔/太平洋岛民（OR：1.13，95%CI：0.98-1.30）。
慢性 HBV 感染与男性和女性、白人和亚裔/太平洋岛民以及非糖尿病患者的 CKD 发生率略有增加和 ESRD 风险增加相关。
