McDonald J K, Tigges J, Tigges M, Reich C
Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322.
Cell Tissue Res. 1988;254(3):499-509. doi: 10.1007/BF00226499.
The purpose of this study was to examine the development and distribution of neuropeptide Y-immunoreactive fibers in the neurohypophysis of the rhesus monkey (Macaca mulatta) throughout life and the relationship of these fibers to the hypothalamo-hypophyseal portal vasculature. In rhesus monkeys, which varied in age from fetal life to 34 years, neuropeptide Y-immunoreactive fibers were present at all ages examined. In adult monkeys, varicose neuropeptide Y-labeled fibers were concentrated in the upper infundibular stem in association with capillary loops of the portal vasculature and the long portal vessels. Other fibers travelled down the infundibular stem and were distributed at the junction of the lower infundibular stem and infundibular process in the vicinity of the short portal vessels. In the infundibular process, neuropeptide Y-immunoreactive fibers were concentrated along the border of the intermediate lobe. Other stained fibers were sparsely distributed in the infundibular process and were often associated with small vessels. Neuropeptide Y-immunoreactivity was also located in a few fibers and cells of the intermediate lobe. Very few labeled fibers were seen in the fetal neurohypophysis, but their number increased gradually during the first postnatal year. At two years of age, a high density of stained fibers was observed, especially in the infundibular process. The number of axons in the infundibular process was lower at 12 years and continued to decline until 34 years of age. Neuropeptide Y may modulate hormone release at these sites and may also be released directly into vessels in the infundibular process. The close association of neuropeptide Y-labeled fibers with capillaries of the portal vasculature strongly suggests that neuropeptide Y is released into the portal blood of monkeys throughout life and may influence hormone secretion from the anterior pituitary gland.
本研究的目的是研究恒河猴（猕猴）神经垂体中神经肽Y免疫反应性纤维在其一生中的发育和分布情况，以及这些纤维与下丘脑 - 垂体门脉血管系统的关系。在年龄从胎儿期到34岁不等的恒河猴中，在所检查的所有年龄段均存在神经肽Y免疫反应性纤维。在成年猴中，有曲张的神经肽Y标记纤维集中在上部漏斗干，与门脉血管系统的毛细血管袢和长门脉血管相关。其他纤维沿漏斗干下行，分布在下部漏斗干与漏斗柄交界处附近的短门脉血管周围。在漏斗柄中，神经肽Y免疫反应性纤维集中在中间叶的边界处。其他染色纤维稀疏分布在漏斗柄中，且常与小血管相关。神经肽Y免疫反应性也位于中间叶的一些纤维和细胞中。在胎儿神经垂体中可见极少的标记纤维，但在出生后的第一年其数量逐渐增加。在两岁时，观察到染色纤维的高密度，尤其是在漏斗柄中。在12岁时漏斗柄中的轴突数量减少，并持续下降直至34岁。神经肽Y可能在这些部位调节激素释放，也可能直接释放到漏斗柄中的血管中。神经肽Y标记纤维与门脉血管系统毛细血管的紧密关联强烈表明，神经肽Y在恒河猴一生中都释放到门脉血中，并可能影响垂体前叶的激素分泌。
