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蛋白质和机械应变对正畸复合弓丝耐腐蚀性和细胞毒性的影响。

Effect of Protein and Mechanical Strain on the Corrosion Resistance and Cytotoxicity of the Orthodontic Composite Arch Wire.

作者信息

He Longwen, Cui Ye, Zhang Chao

机构信息

Orthodontic Department, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China.

出版信息

ACS Omega. 2020 Apr 9;5(15):8992-8998. doi: 10.1021/acsomega.0c00803. eCollection 2020 Apr 21.

DOI:10.1021/acsomega.0c00803
PMID:32337463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7178770/
Abstract

In this study, the effects of the exposure to different types of salivary proteins (fibrinogen, IgG, and mucin) and application of an in vitro bending strain on the laser welding orthodontic composite arch wire (CAW) were investigated, and the resultant corrosion behavior and cytotoxicity were studied in vitro. The purpose was to determine the mechanisms by which protein exposure and bending loads contribute to the corrosion of the CAW either alone or in combination by mimicking the clinical application. The results showed that the application of a mechanical strain significantly decreased the corrosion resistance of the CAW and increased the release of toxic corrosion products. The addition of the proteins inhibited the corrosion of the CAW, but the mechanical loads counteracted this effect. Mucin enhanced the corrosion resistance of the CAW. The effects of the proteins or strain, either alone or in combination, should be considered in the application of medical materials of heterogenetic alloys.

摘要

在本研究中，研究了暴露于不同类型唾液蛋白（纤维蛋白原、免疫球蛋白G和粘蛋白）以及体外施加弯曲应变对激光焊接正畸复合弓丝（CAW）的影响，并在体外研究了由此产生的腐蚀行为和细胞毒性。目的是通过模拟临床应用来确定蛋白质暴露和弯曲载荷单独或共同导致CAW腐蚀的机制。结果表明，施加机械应变显著降低了CAW的耐腐蚀性，并增加了有毒腐蚀产物的释放。蛋白质的添加抑制了CAW的腐蚀，但机械载荷抵消了这种作用。粘蛋白增强了CAW的耐腐蚀性。在异种合金医用材料的应用中，应考虑蛋白质或应变单独或共同产生的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d5/7178770/d91fac06dc37/ao0c00803_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d5/7178770/42e296d05128/ao0c00803_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d5/7178770/d91fac06dc37/ao0c00803_0008.jpg

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