Department of Orthodontics, Jilin University, No. 1500 Qinghua Road, Changchun, 130021, People's Republic of China.
Ann Biomed Eng. 2014 Jan;42(1):222-30. doi: 10.1007/s10439-013-0885-4. Epub 2013 Aug 6.
Composite arch-wire (CoAW) is an arch wire formed by solder connection of nickel titanium shape memory alloy and stainless steel wire. The purpose of the present study was to investigate the biocompatibility of CoAW as an important foundation for its clinical application. The electrochemical corrosion and ion release behavior of CoAW upon immersion in solutions simulating oral cavity conditions were measured to evaluate the corrosion behavior of CoAW. Murine L-929 cells were co-cultured with CoAW extract to evaluate the cytotoxicity of the corrosion products in vitro. Polarization tests indicated that CoAW is resistant to corrosion in the tested artificial saliva (AS)-based solutions (chloric solution, simple AS, fluorinated AS, and protein-containing AS), and the amount of toxic copper ions released after immersion was lower than average daily dietary intake levels. The cytotoxicity experiments demonstrated the in vitro biocompatibility of CoAW. Based on the combined advantages of its base materials CoAW, with its resistance to biocorrosion and in vitro cytocompatibility, is a promising alternative material for use in orthodontic fixation applications.
复合弓丝（CoAW）是由镍钛形状记忆合金和不锈钢丝通过焊接连接而成的弓丝。本研究旨在探讨 CoAW 的生物相容性，为其临床应用奠定重要基础。通过测量 CoAW 在模拟口腔环境的溶液中浸泡时的电化学腐蚀和离子释放行为来评估 CoAW 的腐蚀行为。将 CoAW 浸提液与鼠 L-929 细胞共培养，评估腐蚀产物的体外细胞毒性。极化试验表明，CoAW 在测试的人工唾液（AS）基溶液（含氯溶液、简单 AS、含氟 AS 和含蛋白 AS）中具有抗腐蚀性，浸泡后释放的有毒铜离子量低于每日平均膳食摄入量。细胞毒性实验表明 CoAW 的体外生物相容性良好。基于其基础材料 CoAW 的综合优势，CoAW 具有抗生物腐蚀性和体外细胞相容性，是一种有前途的正畸固定应用替代材料。
