The corrosion resistance, cytotoxicity, and antibacterial properties of lysozyme coatings on orthodontic composite arch wires.

: The corrosion resistance of new orthodontic composite arch wires (CAWs), which have excellent mechanical properties in a simulated oral environment, must be improved. This study explored the susceptibility to corrosion, cytotoxicity, and antibacterial properties of lysozyme-coated CAWs. : Lysozyme coating of laser-welded CAW surfaces was prepared by liquid phase deposition. Four groups of CAW specimens were prepared: uncoated CAWs and CAWs coated with 20, 40, and 60 g L lysozyme. The surface morphology of the lysozyme coatings was characterized by atomic force microscopy. The samples were immersed in artificial saliva (AS) for 2 weeks, and corrosion morphology was then observed by scanning electron microscopy. Corrosion behavior was characterized according to weight loss and electrochemical properties. The cytotoxicity and antibacterial properties of lysozyme-coated CAWs were assessed by cell counting kit-8 assay and a live/dead bacterial test, respectively. : Surfaces in the three lysozyme coating groups exhibited film-like deposition, the thickness of which increased with the lysozyme concentration. Surface pitting and copper ion precipitation decreased with increasing lysozyme concentration in coatings. The corrosion tendency declined as the corrosion and pitting potentials decreased. The corrosion morphology and electrochemical parameters together indicated that lysozyme coatings increased corrosion resistance. The coatings also reduced cytotoxicity to L-929 cells and increased anti- ability. : Lysozyme coating of CAW surfaces by liquid phase deposition improved the corrosion resistance of CAWs. The protective coatings improved biocompatibility and endowed the CAW surfaces with certain degrees of anti- activity. Different lysozyme concentrations had different protective effects, with 40 g L maybe being the ideal lysozyme concentration for CAW coatings.