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脊柱内固定术后金属过敏反应:何时怀疑,如何治疗。

Metal Hypersensitivity After Spinal Instrumentation: When to Suspect and How to Treat.

机构信息

Department of Neurosurgery, Mayo Clinic, Scottsdale, Arizona, USA.

Department of Neurosurgery, Mayo Clinic, Scottsdale, Arizona, USA.

出版信息

World Neurosurg. 2020 Jul;139:471-477. doi: 10.1016/j.wneu.2020.04.093. Epub 2020 Apr 24.

Abstract

BACKGROUND

Metal hypersensitivity is a rare complication after spinal implant placement but is related to significant clinical challenges including implant failure and poor wound healing. The incidence is likely underreported secondary to challenges with diagnosis and retreatment options.

CASE DESCRIPTION

We present the case of a 41-year-old woman with metal hypersensitivity 6 years status post anterior lumbar interbody fusion after a previously failed revision procedure who presented with low back pain and abdominal pain with food intolerance. Diagnostics revealed presacral fluid collection, which was negative for infection. A detailed workup ruled out other possible differential diagnoses and confirmed hypersensitivity to nickel. Intraoperatively, the interbody was loose but difficult to remove secondary to scar tissue. Ultimately, it was successfully replaced with a polyetheretherketone interbody, which did not contain nickel.

CONCLUSIONS

Metal hypersensitivity is likely an underreported complication in spine literature that is associated with poor outcomes. Further research to create evidence-based guidelines on diagnosis and retreatment options will facilitate diagnosis, reduce time to revision surgery, and ultimately decrease patient suffering.

摘要

背景

金属过敏是脊柱植入物放置后的一种罕见并发症,但与重大临床挑战相关,包括植入物失败和伤口愈合不良。由于诊断和再治疗方案的挑战,其发病率可能被低估了。

病例描述

我们介绍了一位 41 岁女性的病例,她在先前失败的翻修手术后 6 年行前路腰椎椎间融合术,出现金属过敏,表现为腰痛和腹痛伴食物不耐受。诊断发现骶前积液,无感染。详细检查排除了其他可能的鉴别诊断,并证实对镍过敏。术中发现椎间融合器松动,但由于疤痕组织难以取出。最终,成功更换了不含镍的聚醚醚酮椎间融合器。

结论

金属过敏可能是脊柱文献中报道较少的并发症,与不良结局相关。进一步研究以制定基于证据的诊断和再治疗方案指南将有助于诊断、缩短翻修手术时间,并最终减轻患者痛苦。

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