抗真菌药物筛选：跳出固有思维，寻找新型抗真菌支架。
Antifungal drug screening: thinking outside the box to identify novel antifungal scaffolds.
机构信息
Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
出版信息
Curr Opin Microbiol. 2020 Oct;57:1-6. doi: 10.1016/j.mib.2020.03.005. Epub 2020 Apr 24.
Abstract
Invasive fungal infections are responsible for a significant disease burden worldwide. Drugs to treat these infections are limited to only four unique classes, and despite these available treatments, mortality rates remain unacceptably high. In this review, we will discuss antifungal drug screening and how the approach to identifying novel compounds needs move away from traditional growth-based assays in order to meet the demand for new drugs. We highlight specific examples of creative screening strategies that increase the likelihood of identifying compounds with desired activities and provide perspective to inspire development of novel screens for the identification of first-in-class antifungals.
摘要
侵袭性真菌感染在全球范围内造成了巨大的疾病负担。用于治疗这些感染的药物仅局限于四种独特的类别，尽管有这些可用的治疗方法，但死亡率仍然高得不可接受。在这篇综述中，我们将讨论抗真菌药物的筛选，以及为了满足新药的需求，确定新型化合物的方法需要如何摆脱传统的基于生长的检测方法。我们重点介绍了一些有创意的筛选策略的具体例子，这些策略增加了发现具有所需活性的化合物的可能性，并提供了新的视角来启发用于鉴定新型抗真菌药物的新筛选方法的开发。
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