Park Samel, Kim Joong Il, Cho Nam-Jun, Oh Se Won, Park Jongkyu, Yoo Ik Dong, Gil Hyo-Wook, Lee Sang Mi
Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea.
Future Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.
J Clin Med. 2020 Apr 23;9(4):1213. doi: 10.3390/jcm9041213.
The symptoms of glufosinate ammonium (GLA) intoxication include gastrointestinal and neurologic symptoms, respiratory failure, and cardiovascular instability. Among these, neurologic symptoms including loss of consciousness, memory impairment, and seizure are characteristic of GLA poisoning. However, the mechanism of brain injury by GLA poisoning is still poorly understood. We investigated nine patients who had performed an F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) scan because of memory impairment caused by GLA ingestion. FDG-PET images of patients with GLA intoxication were compared with 24 age- and sex-matched healthy controls to evaluate whether the patients had abnormal patterns of glucose metabolism in the brain. Decreased glucose metabolism was observed in the inferior frontal and temporal lobes of these patients with GLA intoxication when compared with 24 age- and sex-matched healthy controls. Three patients performed follow-up FDG-PET scans. However, it was shown that the results of the follow-up FDG-PET scans were determined to be inconclusive. Our study showed that memory impairment induced by GLA intoxication was associated with glucose hypometabolism in the inferior frontal and temporal lobes in the brain.
草铵膦中毒的症状包括胃肠道和神经系统症状、呼吸衰竭以及心血管功能不稳定。其中，包括意识丧失、记忆障碍和癫痫发作在内的神经系统症状是草铵膦中毒的特征。然而，草铵膦中毒导致脑损伤的机制仍知之甚少。我们调查了9例因摄入草铵膦导致记忆障碍而进行F-18氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）的患者。将草铵膦中毒患者的FDG-PET图像与24名年龄和性别匹配的健康对照者进行比较，以评估患者大脑中葡萄糖代谢模式是否异常。与24名年龄和性别匹配的健康对照者相比，这些草铵膦中毒患者的额下回和颞叶葡萄糖代谢降低。3例患者进行了FDG-PET随访扫描。然而，结果显示随访FDG-PET扫描结果尚无定论。我们的研究表明，草铵膦中毒引起的记忆障碍与大脑额下回和颞叶葡萄糖代谢减低有关。
