From the Departments of Genetics (R.L.K., D.L.C., S.F.A.G., D.J.R., B.F.V.), University of Pennsylvania.
Corporal Michael J. Crescenz VA Medical Center (R.L.K., M.G.L., S.M.D.).
Circ Genom Precis Med. 2020 Jun;13(3):e002553. doi: 10.1161/CIRCGEN.119.002553. Epub 2020 Apr 27.
Atrial fibrillation is a common cardiovascular disorder, characterized by irregular electrical activity in the upper chambers of the heart. Both chronic cardiometabolic risk factors and genetics have been shown to contribute to the development of atrial fibrillation. Birthweight has also been associated with risk of atrial fibrillation.
In the current study, we utilized a genetic approach to study the effect of birthweight on atrial fibrillation. We used 2-sample Mendelian randomization to consider the impact of birthweight on incident atrial fibrillation using summary data from the Early Growth Genetics Consortium GWAS of birthweight and a large biobank-based GWAS of atrial fibrillation.
Using the framework of 2-sample Mendelian randomization, we found that a 1-SD genetic elevation of birthweight was associated with increased risk of atrial fibrillation (odds ratio, 1.27 [95% CI, 1.14-1.41]; =1×10) with sensitivity analyses demonstrating robustness of this result.
Our findings clarify the directionality of the relationship between birthweight and atrial fibrillation, supporting the growing body of evidence that intrauterine growth has a lifelong impact on cardiovascular health.
心房颤动是一种常见的心血管疾病，其特征是心脏上部腔室的不规则电活动。慢性心脏代谢危险因素和遗传因素都被证明与心房颤动的发生有关。出生体重也与心房颤动的风险有关。
在本研究中，我们利用遗传方法研究了出生体重对心房颤动的影响。我们使用两样本 Mendelian 随机化，利用早期生长遗传学联盟 GWAS 汇总数据中关于出生体重的信息，以及一个基于大型生物库的心房颤动 GWAS，来考虑出生体重对新发心房颤动的影响。
使用两样本 Mendelian 随机化的框架，我们发现，出生体重每增加 1 个标准差，患心房颤动的风险就会增加（优势比，1.27[95%置信区间，1.14-1.41]；=1×10），敏感性分析表明这一结果具有稳健性。
我们的发现阐明了出生体重与心房颤动之间关系的方向性，支持了越来越多的证据表明宫内生长对心血管健康具有终生影响。
