Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, People's Republic of China.
Department of Otolaryngology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Urol Oncol. 2020 Aug;38(8):688.e11-688.e19. doi: 10.1016/j.urolonc.2020.03.003. Epub 2020 Apr 25.
This study assessed the impact of race/ethnicity on penile squamous cell carcinoma (PSCC) incidence rates, clinical characteristics, and outcomes.
Surveillance, Epidemiology and End Results data from 2004 to 2016 was used for this study. We evaluated racial/ethnic differences in clinical characteristics using χ tests. Overall survival (OS) and PSCC-specific survival (PSCC-SS) were estimated using the Kaplan-Meier method, and differences were determined using the log-rank test. Cox regression models were performed to assess independent predictors for PSCC patient survival.
A total of 2,720 PSCC patients were included for incidence analysis, and 2,438 patients were identified for the χ testing and survival analyses.The overall incidence of PSCC during 2004 to 2016 was 0.30 per 100,000. Only non-Hispanic white (NHW) patients had a statistically significant increase in age-adjusted incidence rates (annual percent change = 2.26, 95% confidence interval [CI]: 0.78-3.76; P = 0.01). In univariate analysis, race/ethnicity was an independent prognostic factor for OS and PSCC-SS. After adjusting for age, marital status, income, grade, TNM (tumor, node, metastasis) stage, and treatment strategies, non-Hispanic black patients still had a statistically significant hazard ratio of 1.35 (95% CI: 1.08-1.68; P = 0.007) for OS, and a hazard ratio of 1.36 (95% CI: 1.01-1.82; P = 0.045) for PSCC-SS compared to NHW.
NHW patients had a statistically significant increase in age-adjusted incidence rate during the period 2004 to 2016. Race/ethnicity is an independent prognostic factor for OS and PSCC-SS, and non-Hispanic black were proven to have unfavorable OS and PSCC-SS compared with NHW.
本研究评估了种族/民族对阴茎鳞状细胞癌（PSCC）发病率、临床特征和结局的影响。
本研究使用了 2004 年至 2016 年的监测、流行病学和最终结果数据。我们使用 χ 检验评估了种族/民族之间的临床特征差异。使用 Kaplan-Meier 法估计总生存率（OS）和 PSCC 特异性生存率（PSCC-SS），并使用对数秩检验确定差异。使用 Cox 回归模型评估 PSCC 患者生存的独立预测因素。
共纳入 2720 例 PSCC 患者进行发病率分析，2438 例患者进行 χ 检验和生存分析。2004 年至 2016 年期间，PSCC 的总体发病率为每 10 万人 0.30。只有非西班牙裔白人（NHW）患者的年龄调整发病率有统计学显著增加（年变化率=2.26，95%置信区间[CI]：0.78-3.76；P=0.01）。在单因素分析中，种族/民族是 OS 和 PSCC-SS 的独立预后因素。在校正年龄、婚姻状况、收入、分级、TNM（肿瘤、淋巴结、转移）分期和治疗策略后，非西班牙裔黑人患者的 OS 仍具有统计学显著的危险比为 1.35（95%CI：1.08-1.68；P=0.007），PSCC-SS 的危险比为 1.36（95%CI：1.01-1.82；P=0.045）与 NHW 相比。
NHW 患者在 2004 年至 2016 年期间，年龄调整发病率有统计学显著增加。种族/民族是 OS 和 PSCC-SS 的独立预后因素，非西班牙裔黑人的 OS 和 PSCC-SS 比 NHW 差。
