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肿瘤位置可能独立预测阴茎M0期鳞状细胞癌患者的生存率。

Tumor Location May Independently Predict Survival in Patients With M0 Squamous Cell Carcinoma of the Penis.

作者信息

Li Kai, Le Xiang, Wang Jianqing, Fan Caibin, Sun Jian

机构信息

Department of Urology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

出版信息

Front Oncol. 2022 Jul 5;12:927088. doi: 10.3389/fonc.2022.927088. eCollection 2022.

DOI:10.3389/fonc.2022.927088
PMID:35865480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9294313/
Abstract

BACKGROUND

To determine the association between tumor location and both clinicopathological characteristics and the survival of patients with M0 squamous cell carcinoma of the penis (SCCP).

METHODS

Data of 455 patients diagnosed with M0 SCCP between 1975 and 2018 were collected from the Surveillance, Epidemiology, and End Results (SEER) database of the United States National Cancer Institute. The effects of tumor location on overall survival (OS) and penile carcinoma-specific survival (PCSS) were analyzed using the Kaplan-Meier method. The Cox proportional hazards regression model was used to determine the impact of tumor location on PCSS.

RESULTS

SCCP was more likely to occur in the prepuce or glans (90%). Although no significant difference was observed between the OS of patients with M0 SCCP in the prepuce or glans and those with M0 SCCP in the body of the penis (p = 0.307), the former had better PCSS (p = 0.024). Moreover, M0 SCCP in the prepuce or glans was also significantly associated with better PCSS in patients with advanced age (age ≥ 60 years, p = 0.011), other ethnicities (p = 0.003), T2-T4 stage (p = 0.036), larger tumors (≥3 cm, p = 0.001), no regional lymph nodes removed (p = 0.044), and radical surgery (p = 0.027). Multivariate analysis confirmed that tumor location is an independent prognostic factor for patients with M0 SCCP [hazard ratio (HR) 1.881, p = 0.026].

CONCLUSIONS

Tumor location is an independent prognostic factor for patients with M0 SCCP, and tumors in the prepuce or glans portend better PCSS.

摘要

背景

确定阴茎M0期鳞状细胞癌（SCCP）患者的肿瘤位置与临床病理特征及生存之间的关联。

方法

收集1975年至2018年间在美国国立癌症研究所监测、流行病学和最终结果（SEER）数据库中诊断为M0期SCCP的455例患者的数据。采用Kaplan-Meier法分析肿瘤位置对总生存期（OS）和阴茎癌特异性生存期（PCSS）的影响。使用Cox比例风险回归模型确定肿瘤位置对PCSS的影响。

结果

SCCP更易发生于包皮或龟头（90%）。虽然包皮或龟头M0期SCCP患者与阴茎体部M0期SCCP患者的OS无显著差异（p = 0.307），但前者的PCSS更好（p = 0.024）。此外，包皮或龟头的M0期SCCP在老年患者（年龄≥60岁，p = 0.011）、其他种族（p = 0.003）、T2-T4期（p = 0.036）、肿瘤较大（≥3 cm，p = 0.001）、未切除区域淋巴结（p = 0.044）以及接受根治性手术（p = 0.027）的患者中也与更好的PCSS显著相关。多因素分析证实肿瘤位置是M0期SCCP患者的独立预后因素[风险比（HR）1.881，p = 0.026]。

结论

肿瘤位置是M0期SCCP患者的独立预后因素，包皮或龟头的肿瘤预示着更好的PCSS。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/1755eea183d4/fonc-12-927088-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/a695fc0767bc/fonc-12-927088-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/1755eea183d4/fonc-12-927088-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/b2add1caad9b/fonc-12-927088-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/234f611aa8d7/fonc-12-927088-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/87e22956c54d/fonc-12-927088-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/a695fc0767bc/fonc-12-927088-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/f0489ac4506b/fonc-12-927088-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/9294313/1755eea183d4/fonc-12-927088-g009.jpg

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