Clinical Pharmacokinetics Unit, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria.
Department of Pathology, Medical University of Innsbruck, Innsbruck, Austria.
Antimicrob Agents Chemother. 2020 Jun 23;64(7). doi: 10.1128/AAC.00275-20.
Anidulafungin and micafungin were quantified in cerebrospinal fluid (CSF) of critically ill adults and in cerebral cortex of deceased patients. In CSF, anidulafungin levels (<0.01 to 0.66 μg/ml) and micafungin levels (<0.01 to 0.16 μg/ml) were lower than those in plasma concentrations (0.77 to 5.07 and 1.21 to 8.70 μg/ml, respectively) drawn simultaneously. In cerebral cortex, anidulafungin and micafungin levels were 0.21 to 2.34 and 0.18 to 2.88 μg/g, respectively. Thus, MIC values of several pathogenic strains exceed concentrations in CSF and in brain.
棘白菌素类（anidulafungin 和 micafungin）在重症患者的脑脊液（CSF）和已故患者的大脑皮质中被定量检测。在 CSF 中，棘白菌素类（anidulafungin 和 micafungin）的水平（<0.01 至 0.66μg/ml）低于同时抽取的血浆浓度（0.77 至 5.07 和 1.21 至 8.70μg/ml）。在大脑皮质中，棘白菌素类（anidulafungin 和 micafungin）的水平分别为 0.21 至 2.34 和 0.18 至 2.88μg/g。因此，几种致病菌株的 MIC 值超过了 CSF 和大脑中的浓度。
