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2
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3
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Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates.10 年间血流感染分离株全球采集的光滑念珠菌分离株中 fks 突变的频率。
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2
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本文引用的文献

1
Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?使用CLSI和EUCAST方法检测念珠菌属对卡泊芬净的最低抑菌浓度（MIC）的实验室间变异性：临床实验室是否应该检测这种药物？
Antimicrob Agents Chemother. 2013 Dec;57(12):5836-42. doi: 10.1128/AAC.01519-13. Epub 2013 Sep 9.
2
Caspofungin MICs correlate with treatment outcomes among patients with Candida glabrata invasive candidiasis and prior echinocandin exposure.棘白菌素 MIC 与既往棘白菌素暴露的光滑念珠菌侵袭性念珠菌病患者的治疗结局相关。
Antimicrob Agents Chemother. 2013 Aug;57(8):3528-35. doi: 10.1128/AAC.00136-13. Epub 2013 May 13.
3
Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations.棘白菌素类耐药性在光滑念珠菌中的增加：临床失败与 FKS 突变和最低抑菌浓度升高相关。
Clin Infect Dis. 2013 Jun;56(12):1724-32. doi: 10.1093/cid/cit136. Epub 2013 Mar 13.
4
The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrata.棘白菌素治疗失败的独立危险因素是侵袭性念珠菌病（由光滑念珠菌引起）患者存在 FKS 突变而不是 MIC。
Antimicrob Agents Chemother. 2012 Sep;56(9):4862-9. doi: 10.1128/AAC.00027-12. Epub 2012 Jul 2.
5
Comparison of the Sensititre YeastOne colorimetric antifungal panel with CLSI microdilution for antifungal susceptibility testing of the echinocandins against Candida spp., using new clinical breakpoints and epidemiological cutoff values.比较 Sensititre YeastOne 比色法抗真菌药敏检测板与 CLSI 微量稀释法对抗真菌药物对念珠菌属的药敏试验，采用新的临床折点和流行病学切点值。
Diagn Microbiol Infect Dis. 2012 Aug;73(4):365-8. doi: 10.1016/j.diagmicrobio.2012.05.008. Epub 2012 Jun 20.
6
Comparison of dimethyl sulfoxide and water as solvents for echinocandin susceptibility testing by the EUCAST methodology.比较二甲基亚砜和水作为 EUCAST 方法进行棘白菌素药敏试验的溶剂。
J Clin Microbiol. 2012 Jul;50(7):2509-12. doi: 10.1128/JCM.00791-12. Epub 2012 Apr 25.
7
Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials.治疗策略对念珠菌血症和其他形式侵袭性念珠菌病患者结局的影响：随机试验的患者水平定量评价。
Clin Infect Dis. 2012 Apr;54(8):1110-22. doi: 10.1093/cid/cis021. Epub 2012 Mar 12.
8
EUCAST technical note on anidulafungin.EUCAST 关于安尼鲁单抗的技术说明。
Clin Microbiol Infect. 2011 Nov;17(11):E18-20. doi: 10.1111/j.1469-0691.2011.03647.x. Epub 2011 Sep 16.
9
Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria.重新审视棘白菌素类药物和念珠菌的临床折点：整合分子、临床和微生物学数据，以制定出基于物种的解释标准。
Drug Resist Updat. 2011 Jun;14(3):164-76. doi: 10.1016/j.drup.2011.01.004. Epub 2011 Feb 24.
10
Comparison of European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Etest methods with the CLSI broth microdilution method for echinocandin susceptibility testing of Candida species.比较欧洲抗菌药物敏感性试验委员会 (EUCAST) 和 Etest 方法与 CLSI 肉汤微量稀释法检测念珠菌属对棘白菌素类药物敏感性。
J Clin Microbiol. 2010 May;48(5):1592-9. doi: 10.1128/JCM.02445-09. Epub 2010 Mar 24.

阿尼芬净和米卡芬净的 MIC 折点优于卡泊芬净，可用于鉴定 FKS 突变的光滑念珠菌菌株和棘白菌素耐药性。

Anidulafungin and micafungin MIC breakpoints are superior to that of caspofungin for identifying FKS mutant Candida glabrata strains and Echinocandin resistance.

机构信息

Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

出版信息

Antimicrob Agents Chemother. 2013 Dec;57(12):6361-5. doi: 10.1128/AAC.01451-13. Epub 2013 Sep 23.

DOI:10.1128/AAC.01451-13
PMID:24060873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3837909/
Abstract

By CLSI interpretive criteria, anidulafungin and micafungin MICs determined by various methods were sensitive (60 to 70%) and highly specific (94 to 100%) for identifying FKS mutations among 120 Candida glabrata isolates. Anidulafungin and micafungin breakpoints were more specific than CLSI's caspofungin breakpoint in identifying FKS mutant strains and patients with invasive candidiasis who were likely to fail echinocandin treatment (P ≤ 0.0001 for both). Echinocandin MICs were most useful clinically when interpreted in the context of prior echinocandin exposure.

摘要

根据 CLSI 解释标准，通过各种方法确定的安尼拉fungin 和米卡fungin MIC 对鉴定 120 株光滑念珠菌分离株中的 FKS 突变具有高敏感性（60-70%）和高特异性（94-100%）。安尼拉fungin 和米卡fungin 折点比 CLSI 的卡泊芬净折点更能准确识别 FKS 突变株和侵袭性念珠菌病患者，这些患者可能对棘白菌素治疗无效（两者均 P≤0.0001）。当棘白菌素 MIC 与既往棘白菌素暴露情况结合进行解释时，在临床上最具参考价值。