Walther F J
Department of Pediatrics, Academic Hospital Maastricht, State University of Limburg, The Netherlands.
Early Hum Dev. 1988 Nov;18(1):1-11. doi: 10.1016/0378-3782(88)90038-2.
Twenty-four term infants with disproportionate intrauterine growth retardation (SGA group) and 24 normally grown term infants matched for age, sex, birth rank and social class were followed from birth until 7 years of age. Both groups were free from perinatal complications and chronic diseases. The children in the SGA group continued to be underweight-for-height with a low ponderal index and a relatively small head circumference at the age of 7 years. Only minor shifts occurred in the individual growth curves since the age of 3 years. In 12 SGA children and 1 control multiple 'soft' neurological signs were found. Their grammar school teachers observed problematic behavior (hyperactivity, poor concentration and clumsiness) in 9 and academic problems in 5 of the 12 SGA children with neurological dysfunction. These findings indicate that disproportionate intrauterine growth retardation at term can have long-term effects on growth and development.
对24名患有不对称性宫内生长迟缓的足月儿（SGA组）以及24名年龄、性别、出生顺序和社会阶层相匹配的正常生长足月儿进行了从出生到7岁的随访。两组均无围产期并发症和慢性疾病。SGA组儿童在7岁时身高别体重仍偏低，体重指数低，头围相对较小。自3岁起，个体生长曲线仅发生了轻微变化。在12名SGA儿童和1名对照儿童中发现了多个“软”神经体征。他们的小学老师观察到，在12名有神经功能障碍的SGA儿童中，9名有行为问题（多动、注意力不集中和笨拙），5名有学习问题。这些发现表明，足月时的不对称性宫内生长迟缓会对生长发育产生长期影响。
