Barcelona Supercomputing Centre (BSC-CNS), 08034 Barcelona, Spain.
Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Nucleic Acids Res. 2020 Jul 2;48(W1):W553-W557. doi: 10.1093/nar/gkaa282.
Inferring homology relationships across genes in different species is a central task in comparative genomics. Therefore, a large number of resources and methods have been developed over the years. Some public databases include phylogenetic trees of homologous gene families which can be used to further differentiate homology relationships into orthology and paralogy. MetaPhOrs is a web server that integrates phylogenetic information from different sources to provide orthology and paralogy relationships based on a common phylogeny-based predictive algorithm and associated with a consistency-based confidence score. Here we describe the latest version of the web server which includes major new implementations and provides orthology and paralogy relationships derived from ∼8.2 million gene family trees-from 13 different source repositories across ∼4000 species with sequenced genomes. MetaPhOrs server is freely available, without registration, at http://orthology.phylomedb.org/.
推断不同物种中基因之间的同源关系是比较基因组学的一项核心任务。因此，多年来已经开发了大量的资源和方法。一些公共数据库包括同源基因家族的系统发育树，可用于进一步将同源关系细分为直系同源和旁系同源。MetaPhOrs 是一个整合来自不同来源的系统发育信息的网络服务器，它提供基于共同系统发育的预测算法的直系同源和旁系同源关系，并附有基于一致性的置信得分。在这里，我们描述了该网络服务器的最新版本，它包括主要的新实现，并提供了来自约 4000 个具有测序基因组的物种的约 820 万个基因家族树的直系同源和旁系同源关系。MetaPhOrs 服务器可在无需注册的情况下免费使用，网址是 http://orthology.phylomedb.org/。
