生物大分子用于眼部疾病治疗的眼科药物传递。
Biological macromolecules for ophthalmic drug delivery to treat ocular diseases.
机构信息
Department of Pharmaceutical Technology, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India; National Facility on Bioactive Peptides from Milk, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India.
Department of Pharmaceutical Technology, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India; National Facility for Drug Development, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India; National Facility on Bioactive Peptides from Milk, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India.
出版信息
Int J Biol Macromol. 2018 Apr 15;110:7-16. doi: 10.1016/j.ijbiomac.2018.01.120. Epub 2018 Jan 31.
Development of newer drug carrier systems by the researchers has resulted in numerous breakthroughs in the development and manufacturing of ocular products. The ocular bioavailability of drugs at the posterior segment of the eye is a challenging task in the present scenario. Naturally derived macromolecular carriers are widely used to increase the efficacy of ocular drugs. They provide enhanced corneal permeability and retention effect at the surface of cornea for a prolonged period of time. In this regimen the present review focuses towards the major ocular diseases and their prevalence and development of efficient drug carrier systems utilizing various naturally derived macromolecules for improved delivery of drugs to treat ocular diseases.
研究人员开发的新型药物载体系统在眼部产品的开发和制造方面取得了许多突破。在当前情况下，药物在后眼部的眼部生物利用度是一项具有挑战性的任务。天然衍生的大分子载体广泛用于提高眼部药物的疗效。它们在较长时间内提供增强的角膜通透性和在角膜表面的保留效果。在这种方案中，本综述侧重于主要眼部疾病及其流行情况以及利用各种天然衍生的大分子开发有效的药物载体系统，以改善药物输送以治疗眼部疾病。
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