Wei Edward T
School of Public Health, University of California, Berkeley, 2121 Berkeley Way #5302, Berkeley, CA 94720-7360, United States.
Med Hypotheses. 2020 Sep;142:109747. doi: 10.1016/j.mehy.2020.109747. Epub 2020 Apr 21.
Heat impairs human learning and work output when environmental temperatures increase from 18 °C → 25+°C. The hypothesis here is that if the localized, ambient milieu around the upper eyelid margin is perceived as being ~15 °C in coolness, then the adverse effects of heat can be attenuated. This is achieved by topical wipe of a solution to the closed eyelid skin above the eyelashes. The receptor target is TRPM8, an integral membrane protein that transduces the sense of coolness/cold to the central nervous system. The wipe solution contains a TRPM8 agonist called cryosim-3 (1-diisopropylphosphorylnonane) at 1-3 mg/mL in water and designed for delivery to the eyelid margin. Other sensory systems negatively affected by heat, such as the surfaces of the nasal cavity, can also be treated with the TRPM8 agonist as an adjunct to relieve discomfort from the heat.
当环境温度从18°C升至25°C以上时，高温会损害人类的学习能力和工作效率。这里的假设是，如果上睑缘周围局部的环境温度被感知为凉爽的~15°C，那么高温的不利影响就可以得到缓解。这是通过将一种溶液局部擦拭在睫毛上方闭合的眼睑皮肤上实现的。受体靶点是TRPM8，一种将凉爽/寒冷感觉传导至中枢神经系统的整合膜蛋白。擦拭溶液含有一种名为cryosim-3（1-二异丙基磷酰基壬烷）的TRPM8激动剂，其在水中的浓度为1-3mg/mL，专为输送到眼睑边缘而设计。其他受高温负面影响的感觉系统，如鼻腔表面，也可以用TRPM8激动剂进行治疗，作为缓解高温不适的辅助手段。
