Cao W J, Yao Y M, Wei W, Lin F, Lu J D, Yuan Z
Institute of AIDS/STD/Dermatology Prevention and Treatment, Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Apr 10;41(4):557-561. doi: 10.3760/cma.j.cn112338-20190604-00395.
To examine the survival time and related factors on HIV/AIDS patients in Guizhou province from 1995 to 2018. A retrospective cohort study was conducted to analyze the HIV/AIDS case from 1995 to 2018 in Guizhou province with data gathered from the "Chinese National Comprehensive HIV/AIDS Prevention and care Information system". Survival rate was calculated by life table and survival time was estimated by Kaplan-Meier. Related factors on survival time were analyzed by Cox regression model. A total of 53 232 HIV/AIDS cases were included in the study, with the mortality rate as 8.53/100 person-years (14 210/166 679.18), median survival time as 10.20 (95: 9.91-10.48) years, and survival rates of 1, 5, 10 and 20 years as 0.85, 0.68, 0.51, 0.36, 0.19 respectively. Results from the multivariate Cox regression analysis showed that factors as: being male (compared with females, a=0.757, 95: 0.727-0.788), with antiviral treatment (ART) (compared with those without ART, a=0.173, 95: 0.165-0.181), CD(4)<200 cells/μl[compared with CD(4)(+)T cells (CD(4)) ≥200 cells/μl, a=0.410, 95: 0.387-0.435], age ≥45 (compared with age<45, a=1.506, 95: 1.193-1.901), illiterate (compared with having high school education or above, a=0.904, 95: 0.832-0.982), unmarried (compared with divorced or widowed, a=0.896, 95: 0.848-0.946), through heterosexual transmission (compared with homosexual transmission, a=0.555, 95: 0.487-0.632), ethnic minorities (compared with Hans, a=1.185, 95: 1.114-1.262), and farmers/migrant workers (compared with domestic/unemployed,a=0.874, 95: 0.834-0.916,) ., were related to the survival time of HIV/AIDS, in Guizhou province. The mortality rate of HIV/AIDS in Guizhou province appeared relatively high, but with no obvious downward trend seen in the last years. Factors as being male, age ≥45, low education level, ethnic minorities, CD(4)<200 cells/μl were identified as related to the HIV/AIDS survival time. We would suggest that treatment and follow-up management programs should be strengthened to improve the quality of life among these patients.
为研究1995年至2018年贵州省艾滋病病毒/艾滋病(HIV/AIDS)患者的生存时间及相关因素。开展一项回顾性队列研究,分析1995年至2018年贵州省的HIV/AIDS病例,数据来源于“中国国家艾滋病综合防治信息系统”。采用寿命表计算生存率,用Kaplan-Meier法估计生存时间。通过Cox回归模型分析生存时间的相关因素。本研究共纳入53232例HIV/AIDS病例,死亡率为8.53/100人年(14210/166679.18),中位生存时间为10.20(95%CI:9.91-10.48)年,1年、5年、10年和20年生存率分别为0.85、0.68、0.51、0.36、0.19。多因素Cox回归分析结果显示,男性(与女性相比,a=0.757,95%CI:0.727-0.788)、接受抗病毒治疗(ART)(与未接受ART者相比,a=0.173,95%CI:0.165-0.181)、CD4<200个细胞/μl[与CD4(+)T细胞(CD4)≥200个细胞/μl相比,a=0.410,95%CI:0.387-0.435]、年龄≥45岁(与年龄<45岁相比,a=1.506,95%CI:1.193-1.901)、文盲(与高中及以上学历相比,a=0.904,95%CI:0.832-0.982)、未婚(与离异或丧偶相比,a=0.896,95%CI:0.848-0.946)、经异性传播(与同性传播相比,a=0.555,95%CI:0.487-0.632)、少数民族(与汉族相比,a=1.185,95%CI:1.114-1.262)以及农民/农民工(与家庭主妇/无业者相比,a=0.874,95%CI:0.834-0.916)等因素与贵州省HIV/AIDS患者的生存时间有关。贵州省HIV/AIDS死亡率相对较高,但近年来无明显下降趋势。男性、年龄≥45岁、低教育水平、少数民族、CD4<200个细胞/μl等因素被确定与HIV/AIDS生存时间有关。建议加强治疗和随访管理项目,以提高这些患者的生活质量。