Lin Jason, Peng Chuanqi, Ravi Sanjana, Siddiki A K M Nur Alam, Zheng Jie, Balkus Kenneth J
Department of Chemistry and Biochemistry of the University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USA.
Materials (Basel). 2020 Apr 24;13(8):1998. doi: 10.3390/ma13081998.
Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery.
对具有可控粒径和高比表面积的联苯皱状介孔二氧化硅纳米颗粒进行了阿霉素储存和递送方面的评估。平均粒径和约表面积分别为~70纳米和约1100平方米/克。阿霉素负载效率为38.2±1.5（w/w）%，且释放呈pH依赖性。乳腺癌细胞系MCF-7（密歇根癌症基金会-7）用于体外药物释放研究。负载阿霉素的纳米颗粒的细胞毒性显著高于游离阿霉素。荧光图像显示MCF-7细胞摄取了联苯皱状介孔二氧化硅（BPWS）。联苯桥连的皱状二氧化硅纳米颗粒在疏水性药物负载和递送方面似乎很有前景。
