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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Andersson G, Garwicz M, Hesslow G

Department of Physiology and Biophysics, University of Lund, Sweden.

Exp Brain Res. 1988;72(3):450-6. doi: 10.1007/BF00250590.

Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.

通过以“高”频率（大于3赫兹）对周围神经进行15 - 25秒的刺激来激活攀缘纤维，然后以0.9赫兹的频率刺激约1分钟。高频激活诱导了从小脑表面记录的攀缘纤维反应的条件后抑制，持续长达约1分钟。2. 在小脑上脚（结合臂）进行电解损伤。损伤后，条件后抑制完全消除。3. 向下橄榄核注射GABA受体阻断剂甲碘化荷包牡丹碱可可逆地阻断条件后抑制。4. 这些结果支持了安德森和赫斯洛（1987a）提出的假说，即条件后抑制是由GABA能中间核 - 橄榄核通路介导的。

Andersson G, Garwicz M, Hesslow G

Department of Physiology and Biophysics, University of Lund, Sweden.

Exp Brain Res. 1988;72(3):450-6. doi: 10.1007/BF00250590.

Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.

通过以“高”频率（大于3赫兹）对周围神经进行15 - 25秒的刺激来激活攀缘纤维，然后以0.9赫兹的频率刺激约1分钟。高频激活诱导了从小脑表面记录的攀缘纤维反应的条件后抑制，持续长达约1分钟。2. 在小脑上脚（结合臂）进行电解损伤。损伤后，条件后抑制完全消除。3. 向下橄榄核注射GABA受体阻断剂甲碘化荷包牡丹碱可可逆地阻断条件后抑制。4. 这些结果支持了安德森和赫斯洛（1987a）提出的假说，即条件后抑制是由GABA能中间核 - 橄榄核通路介导的。