spectroscopic investigation of groove binding interaction of FeO@CaAl-LDH@L-Dopa with calf thymus DNA.

The principal goal of this study is to evaluate the interaction of FeO@CaAl-LDH@L-Dopa and FeO@CaAl-LDH nanoparticles with calf thymus DNA. The magnetic nanoparticles were previously prepared by a chemical co-precipitation method, and the surface of the FeO nanoparticles was coated with CaAl layered double hydroxides. The antiparkinsonian drug "L-Dopa" was carried by this core-shell nanostructure to achieve the drug delivery system with suitable properties for biological applications. Also, the interaction of FeO@CaAl-LDH@L-Dopa and FeO@CaAl-LDH nanoparticles with CT-DNA was studied using, UV-Visible spectroscopy, viscosity, circular dichroism (CD), and fluorescence spectroscopy techniques. The results of investigations demonstrated that FeO@CaAl-LDH@L-Dopa and FeO@CaAl-LDH nanoparticles have interacted via minor groove binding and intercalated to CT-DNA, respectively.