Shabanov P D, Piotrovskiĭ L B, Dumpis M A
Farmakol Toksikol. 1988 Nov-Dec;51(6):29-32.
The effects of four derivatives of imidazole-4(5)-carboxylic acid on the formation and extinction of the conditioned drinking reflex and the preservation of the conditioned response of passive avoidance after electroconvulsive shock or mechanic craniocerebral injury were studied during experiments on rats. N-methylamide of imidazole-4(5)-carboxylic acid exhibited the greatest psychostimulant and antiamnestic activity. Addition of beta-phenylisopropyl radical to NH2-group resulted in the appearance of depressant properties.
在对大鼠进行的实验中，研究了咪唑-4(5)-羧酸的四种衍生物对条件性饮反射的形成与消退以及电休克或机械性颅脑损伤后被动回避条件反应的保持的影响。咪唑-4(5)-羧酸的N-甲酰胺表现出最大的精神兴奋和抗遗忘活性。在NH2基团上添加β-苯异丙基会导致出现抑制特性。
