Zamatkin S M, Lis R E
Arkh Anat Gistol Embriol. 1990 May;98(5):27-33.
By means of the quantitative histochemical method aldehyde dehydrogenase (1.2.1.3; AlDH) activity has been studied in the rat brain and spinal cord structures. AlDH activity (acetaldehyde is used as a substrate) in the barrier structures of the brain (vascular and villous ependymocytes of the cerebral ventricles, endothelium of blood capillaries) makes only 10-30% during the antenatal period and then increases gradually, reaching the activity specific for mature animals by the 20th-40th day after birth. Up to the 10th day of the postnatal development AlDH activity of neurocytes of various types makes 45-70%, and then increases sharply, and by the 20th day is approaches the definitive one. AlDH activity of the spinal cord motoneurons in old rats (2-year-old) essentially surpasses the control. In the white cerebral substance and its gliocytes from the 10th up to the 40th day after birth AlDH activity sharply increases; this coincides with myelinization of the CNS. Dynamics of aldehyde-oxidating ability is probably connected with natural changes in the CNS metabolism during ontogenesis. At the same time, it reflects a low level in stability of the developing brain to the damaging effect of exogenic ethanol and especially to its toxic metabolite--acetaldehyde.
通过定量组织化学方法，对大鼠脑和脊髓结构中的醛脱氢酶（1.2.1.3；AlDH）活性进行了研究。在产前阶段，脑屏障结构（脑室的血管和绒毛室管膜细胞、毛细血管内皮）中的AlDH活性（以乙醛为底物）仅为10%-30%，然后逐渐增加，在出生后第20-40天达到成熟动物特有的活性。在出生后发育的第10天之前，各种类型神经细胞的AlDH活性为45%-70%，然后急剧增加，到第20天时接近最终水平。老年大鼠（2岁）脊髓运动神经元的AlDH活性显著超过对照组。在出生后第10天至40天期间，大脑白质及其神经胶质细胞中的AlDH活性急剧增加；这与中枢神经系统的髓鞘形成相吻合。醛氧化能力的动态变化可能与个体发育过程中中枢神经系统代谢的自然变化有关。同时，它反映出发育中的大脑对外源性乙醇尤其是其有毒代谢物乙醛的损伤作用的稳定性较低。
