瞬时受体电位香草素 1（TRPV1）和磷酸酶张力蛋白同源物（PTEN）在卵巢上皮性癌中的预后意义。
Prognostic Significance of Transient Receptor Potential Vanilloid Type 1 (TRPV1) and Phosphatase and Tension Homolog (PTEN) in Epithelial Ovarian Cancer.
机构信息
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
出版信息
Cancer Genomics Proteomics. 2020 May-Jun;17(3):309-319. doi: 10.21873/cgp.20191.
Abstract
BACKGROUND
Transient receptor potential vanilloid type 1 (TRPV1) has been studied in human malignancies, but has not been studied in epithelial ovarian cancer (EOC). We, therefore, investigated the significance of TRPV1 and correlation with phosphatase and tension homolog (PTEN) in EOC.
MATERIALS AND METHODS
Immunohistochemical analyses for TRPV1 and PTEN were performed using a tissue microarray. Moreover, the role of TRPV1 in cell growth was assessed in a EOC cell line.
RESULTS
High TRPV1 expression and the combination of high TRPV1 and low PTEN expression were an independent prognostic factor for overall survival and disease-free survival. In vitro results demonstrated that knockdown of TRPV1 was associated with decreased cell viability and colony formation.
CONCLUSION
There is a strong association between TRPV1 and PTEN and the combination of TRPV1 and PTEN is a strong indicator of prognostic predictor in EOC.
摘要
背景
瞬时受体电位香草酸亚型 1（TRPV1）已在人类恶性肿瘤中进行了研究，但尚未在卵巢上皮癌（EOC）中进行研究。因此，我们研究了 TRPV1 在 EOC 中的意义及其与磷酸酶和张力蛋白同系物（PTEN）的相关性。
材料与方法
使用组织微阵列对 TRPV1 和 PTEN 进行免疫组织化学分析。此外，还在卵巢癌细胞系中评估了 TRPV1 在细胞生长中的作用。
结果
高 TRPV1 表达以及高 TRPV1 和低 PTEN 表达的组合是总生存和无病生存的独立预后因素。体外结果表明，TRPV1 的敲低与细胞活力和集落形成减少有关。
结论
TRPV1 与 PTEN 之间存在很强的关联，并且 TRPV1 和 PTEN 的组合是 EOC 中预后预测因子的强指标。
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