Phytochemical characteristics of aerial part of (L) and its inhibitory activity against leukemic cells and antioxidant properties.

BACKGROUND AND OBJECTIVES

is a rich bioresource for folk and traditional medicines from ancient times till date. The present study aimed to investigate the free radical scavenging and anticancer efficacy of the ethanolic and methanolic extract from the aerial parts of (L).

MATERIAL AND METHODS

cell-free antioxidant analyses were performed for the ethanolic extract of (L). (EECQ) and methanolic extract of (L). (MECQ) using different free radical scavenging assays includes DPPH, nitric oxide, superoxide, metal chelation, and hydrogen peroxide radical scavenging assays. leukemic cytotoxic assessment by MTT assay was performed both EECQ and MECQ extract against HL-60 cell lines.

RESULTS

Strong antioxidant effects were recorded in EECQ and MECQ in all the cell-free models. The ethanolic extract exhibited a significant dose-dependent free radical activity in comparison with methanolic extracts. The EECQ and MECQ possess pronounced anticancer efficacy against leukemic cells HL-60 with an IC value of 36 μg/mL and 40 μg/mL respectively.

CONCLUSION

Present data indicates the presence of marked antioxidant and anticancer behaviors in the extracts of aerial portions of (L). extracts. Thus, (L). poses as a promising safe chemopreventive plant to combat cancer.