Zuppiroli A, Favilli S, Arfaioli C, Cecchi F, Ciaccheri M, Fratiglioni L, Ginanneschi A, Inzitari D, Italiani G, Nencini P
Servizio di Cardiologia, Ospedale di Careggi, Firenze.
G Ital Cardiol. 1988 Jul;18(7):592-5.
Cardiac sources of emboli have been frequently described in patients with Transitory Ischemic Attacks (TIAs). The aim of our study was to assess the value of two-dimensional echocardiography (2D-E) in the investigation for possible cardiac aetiology of TIAs. As an offshoot of a larger epidemiologic study which aimed at determining the period prevalence of TIAs in 6.504 subject(s) of the general population aged between 40-65, fifty subjects with TIA (group A) and 66 controls (group B) were studied. A heart disease was found in 20/50 s. (40%) in group A (coronary artery disease: 5; hypertensive heart disease: 4; mitral valve prolapse: 5; left ventricular aneurysms: 2; aortic valve disease: 2; aortic valve prosthesis: 1; atrial fibrillation: 1) and in 5/66 s. (7.5%) in group B (p less than 0.01) (coronary disease: 2; hypertensive heart disease: 1; mitral valve prolapse: 2). A potential source of emboli was present in 11 s. in group A (22%) and in 2 s. in group B (3%) (p less than 0.01). In 4/50 s. in group A and in 1/66 in group B the diagnosis was obtained by means of 2D-E only, because other clinical signs and ECG data were negative. 2D-E could only confirm the diagnosis in the remaining cases, with no additional information (i.e., no intracavitary masses were seen). In conclusion there is a high prevalence of heart disease in patients with TIA over 40 years of age. A cardiac source of emboli may be suspected in a substantial number of cases. Nevertheless the value of routine 2D-E in disclosing an otherwise undetected source of emboli is rather low.
短暂性脑缺血发作(TIA)患者的心脏栓子来源已被频繁描述。我们研究的目的是评估二维超声心动图(2D-E)在调查TIA可能的心脏病因方面的价值。作为一项更大的流行病学研究的分支,该研究旨在确定40至65岁普通人群中6504名受试者的TIA期间患病率,对50名TIA患者(A组)和66名对照者(B组)进行了研究。A组中20/50例(40%)发现患有心脏病(冠状动脉疾病:5例;高血压性心脏病:4例;二尖瓣脱垂:5例;左心室动脉瘤:2例;主动脉瓣疾病:2例;主动脉瓣人工瓣膜:1例;心房颤动:1例),B组中5/66例(7.5%)发现患有心脏病(p<0.01)(冠状动脉疾病:2例;高血压性心脏病:1例;二尖瓣脱垂:2例)。A组11例(22%)存在潜在栓子来源,B组2例(3%)存在潜在栓子来源(p<0.01)。A组4/50例和B组1/66例仅通过2D-E获得诊断,因为其他临床体征和心电图数据均为阴性。2D-E仅能在其余病例中证实诊断,无额外信息(即未发现心腔内肿块)。总之,40岁以上TIA患者中心脏病患病率很高。在相当多的病例中可能怀疑有心脏栓子来源。然而,常规2D-E在发现其他未检测到的栓子来源方面的价值相当低。