[天蓝色链霉菌A3(2)中不稳定氯霉素抗性决定子的遗传定位]
[Genetic mapping of unstable chloramphenicol resistance determinant in Streptomyces coelicolor A3(2)].
作者信息
Fedorenko V A, Danilenko V N, Lomovskaia N D
出版信息
Genetika. 1988 Oct;24(10):1768-76.
The results indicative of chromosomal localization of the unstable chloramphenicol resistance determinant in Streptomyces coelicolor A3(2) have been obtained. Independent mutations specifying chloramphenicol sensitivity in different strains of S. coelicolor A3(2), S18 and A617M are localized in the same region flanked by markers argA1 and cysD18 on the genetic map. Mutations restoring chloramphenicol resistance are also localized in this region. Different locations of the genetically unstable determinant of chloramphenicol resistance detected in various laboratories are discussed, in relation to the results showing that transfer to chloramphenicol sensitivity is due to a set of various rearrangements (deletions, amplifications, deamplifications, etc.), differing in separate variants.
已获得表明不稳定氯霉素抗性决定簇在天蓝色链霉菌A3(2)中染色体定位的结果。在天蓝色链霉菌A3(2)的不同菌株S18和A617M中，指定氯霉素敏感性的独立突变位于遗传图谱上由标记argA1和cysD18侧翼的同一区域。恢复氯霉素抗性的突变也位于该区域。结合表明对氯霉素敏感性的转移是由于一组各种重排（缺失、扩增、去扩增等），在不同变体中有所不同的结果，讨论了在各个实验室检测到的遗传不稳定氯霉素抗性决定簇的不同位置。
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