Allergology Clinic, Clinica San Carlo, Paderno Dugnano, Milan, Italy.
Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.
Eur Ann Allergy Clin Immunol. 2021 Jul;53(4):168-170. doi: 10.23822/EurAnnACI.1764-1489.144. Epub 2020 Apr 29.
The clinical usefulness of two commercial peach extracts for SPT (by Lofarma SpA and ALK-Abellò, respectively) was compared in a multicenter study carried out in Italy. Peach allergic patients were tested with the two extracts in parallel and underwent the detection of IgE specific for all three peach allergens currently available (Pru p1, Pru p3, and Pru p4, respectively). The two extracts were almost identical in terms of sensitivity and specificity, being able to detect virtually all patients sensitized to stable peach allergens (lipid transfer protein (LTP) and, presumably, peamaclein) but scoring negative in patients exclusively sensitive to labile allergens (either PR-10 and/or profilin). Thus, the two extracts represent an excellent tool to carry out a preliminary component-resolved diagnosis of peach allergy at the first patient visit.
在意大利进行的一项多中心研究中，比较了两种商业桃提取物（分别来自 Lofarma SpA 和 ALK-Abellò）在 SPT 中的临床应用。将两种提取物平行用于桃过敏患者的检测，并进行目前三种桃过敏原（Pru p1、Pru p3 和 Pru p4）的特异性 IgE 检测。两种提取物在敏感性和特异性方面几乎相同，几乎可以检测到所有对稳定桃过敏原（脂转移蛋白（LTP）和推测的桃蛋白酶）敏感的患者，但对仅对不稳定过敏原（PR-10 和/或丝状蛋白）敏感的患者呈阴性。因此，这两种提取物是在初次就诊时对桃过敏进行初步成分分辨诊断的极好工具。
