Sethiya Ayushi, Agarwal Dinesh Kr, Agarwal Shikha
Department of Chemistry, Synthetic Organic Chemistry Laboratory, MLS University, Udaipur, 313001, India.
Department of Pharmacy, B.N. University, Udaipur, 313001, India.
Mini Rev Med Chem. 2020;20(13):1190-1232. doi: 10.2174/1389557520666200429103647.
Curcumin is a poly phenolic compound extracted from turmeric. Over the past years, it has acquired significant interest among researchers due to its numerous pharmacological activities like anti- cancer, anti-alzheimer, anti-diabetic, anti-bacterial, anti-inflammatory and so on. However, the clinical use of curcumin is still obstructed due to tremendously poor bioavailability, rapid metabolism, lower gastrointestinal absorption, and low permeability through cell that makes its pharmacology thrilling. These issues have led to enormous surge of investigation to develop curcumin nano formulations which can overcome these restrictive causes. The scientists all across the universe are working on designing several drug delivery systems viz. liposomes, micelles, magnetic nano carriers, etc. for curcumin and its composites which not only improve its physiochemical properties but also enhanced its therapeutic applications. The review aims to systematically examine the treasure of information about the medicinal use of curcumin. This article delivers a general idea of the current study piloted to overwhelm the complications with the bioavailability of curcumin which have exhibited an enhanced biological activity than curcumin. This article explains the latest and detailed study of curcumin and its conjugates, its phytochemistry and biological perspectives and also proved curcumin as an efficient drug candidate for the treatment of numerous diseases. Recent advancements and futuristic viewpoints are also deliberated, which shall help researchers and foster commercial translations of improved nanosized curcumin combination for the treatment of various diseases.
姜黄素是从姜黄中提取的一种多酚类化合物。在过去几年中，由于其具有抗癌、抗阿尔茨海默病、抗糖尿病、抗菌、抗炎等多种药理活性，它引起了研究人员的极大兴趣。然而，姜黄素的临床应用仍受到阻碍，因为其生物利用度极低、代谢迅速、胃肠道吸收较差以及细胞通透性低，这些因素使得其药理学特性令人兴奋。这些问题促使人们对开发能够克服这些限制因素的姜黄素纳米制剂进行了大量研究。世界各地的科学家们正在致力于设计多种药物递送系统，如脂质体、胶束、磁性纳米载体等，用于姜黄素及其复合物，这些系统不仅改善了其理化性质，还增强了其治疗应用。这篇综述旨在系统地研究有关姜黄素药用的信息宝库。本文概述了当前为克服姜黄素生物利用度问题而开展的研究，这些研究显示出比姜黄素更强的生物活性。本文解释了姜黄素及其共轭物的最新详细研究、其植物化学和生物学观点，并证明姜黄素是治疗多种疾病的有效候选药物。还讨论了最近的进展和未来的观点，这将有助于研究人员，并促进改进的纳米姜黄素组合用于治疗各种疾病的商业转化。
