Institute of Radiology, Winterthur Cantonal Hospital, Winterthur, Switzerland.
Institute of Diagnostic and Interventional Radiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.
PLoS One. 2020 Apr 29;15(4):e0232372. doi: 10.1371/journal.pone.0232372. eCollection 2020.
Non-Cartesian Spiral readout can be implemented in 3D Time-of-flight (TOF) MR angiography (MRA) with short acquisition times. In this intra-individual comparison study we evaluated the clinical feasibility of Spiral TOF MRA in comparison with compressed sensing accelerated TOF MRA at 1.5T for intracranial vessel imaging as it has yet to be determined.
Forty-four consecutive patients with suspected intracranial vascular disease were imaged with two Spiral 3D TOFs (Spiral, 0.82x0.82x1.2 mm3, 01:32 min; Spiral 0.8, 0.8x0.8x0.8 mm3, 02:12 min) and a Compressed SENSE accelerated 3D TOF (CS 3.5, 0.82x0.82x1.2 mm3, 03:06 min) at 1.5T. Two neuroradiologists assessed qualitative (visualization of central and peripheral vessels) and quantitative image quality (Contrast Ratio, CR) and performed lesion and variation assessment for all three TOFs in each patient. After the rating process, the readers were questioned and representative cases were reinspected in a non-blinded fashion. For statistical analysis, the Friedman and Nemenyi post-hoc test, Kendall W tests, repeated measure ANOVA and weighted Cohen's Kappa tests were used.
The Spiral and Spiral 0.8 outperformed the CS 3.5 in terms of peripheral image quality (p<0.001) and performed equally well in terms of central image quality (p>0.05). The readers noted slight differences in the appearance of maximum intensity projection images. A good to high degree of interstudy agreement between the three TOFs was observed for lesion and variation assessment (W = 0.638, p<0.001 -W = 1, p<0.001). CR values did not differ significantly between the three TOFs (p = 0.534). Interreader agreement ranged from good (K = 0.638) to excellent (K = 1).
Compared to the CS 3.5, both the Spiral and Spiral 0.8 exhibited comparable or better image quality and comparable diagnostic performance at much shorter acquisition times.
非笛卡尔螺旋读取可在 3D 时间飞跃（TOF）磁共振血管造影（MRA）中实现，具有较短的采集时间。在这项个体内比较研究中，我们评估了 Spiral TOF MRA 的临床可行性，与压缩感知加速 TOF MRA 在 1.5T 下进行颅内血管成像进行比较，因为尚未确定。
连续 44 例疑似颅内血管疾病患者接受了两种 Spiral 3D TOF（Spiral，0.82x0.82x1.2mm3，01：32min；Spiral 0.8，0.8x0.8x0.8mm3，02：12min）和压缩感知加速 3D TOF（CS 3.5，0.82x0.82x1.2mm3，03：06min）在 1.5T 下进行成像。两名神经放射科医生评估了定性（中央和外周血管的可视化）和定量图像质量（对比比，CR），并对所有三个 TOF 进行了病变和变异评估每个患者。在评分过程之后，读者被询问并以非盲方式重新检查代表性病例。对于统计分析，使用 Friedman 和 Nemenyi 事后检验，Kendall W 检验，重复测量方差分析和加权 Cohen 的 Kappa 检验。
Spiral 和 Spiral 0.8 在周围图像质量方面优于 CS 3.5（p<0.001），并且在中央图像质量方面表现相当（p>0.05）。读者注意到最大强度投影图像外观的细微差异。在病变和变异评估方面，三种 TOF 之间观察到良好到高度的研究间一致性（W = 0.638，p<0.001-W = 1，p<0.001）。三种 TOF 之间的 CR 值没有显着差异（p = 0.534）。读者间的一致性范围从良好（K = 0.638）到优秀（K = 1）。
与 CS 3.5 相比，Spiral 和 Spiral 0.8 均表现出可比或更好的图像质量和可比的诊断性能，采集时间大大缩短。
