使用压缩感知的 3D 颅内磁共振血管成像的临床可行性研究。
Clinical feasibility study of 3D intracranial magnetic resonance angiography using compressed sensing.
机构信息
Department of Radiology, Peking University First Hospital, Beijing, China.
Philips Research China, Shanghai, China.
出版信息
J Magn Reson Imaging. 2019 Dec;50(6):1843-1851. doi: 10.1002/jmri.26752. Epub 2019 Apr 13.
BACKGROUND
Compressed sensing (CS) has been widely used to improve the speed of MRI, but the feasibility of application in 3D intracranial MR angiography (MRA) needs to be evaluated in clinical practice.
PURPOSE
To evaluate the clinical feasibility of CS-MRA in comparison with conventional 3D-MRA (Con-MRA).
STUDY TYPE
Retrospective.
SUBJECTS
Forty-nine consecutive patients with suspected intracranial arterial disease.
FIELD STRENGTH/SEQUENCE: 3T MRI. 3D time-of-flight (TOF) MRA using a CS algorithm and conventional 3D TOF MRA scan.
ASSESSMENT
Three radiologists (4, 11, and 12 years of experience in neuroradiology) independently assessed the image quality, vascular lesions, and variations of intracranial arteries of both CS-MRA and Con-MRA, respectively.
STATISTICAL TESTS
The Kendall W test was performed to assess the interobserver agreement of image quality and intracranial arterial stenosis. A nonparametric test (Wilcoxon test) was used for comparison of the image quality and definition of the external carotid artery (ECA). Weighted kappa analysis was performed for the interstudy agreement of intracranial arterial stenosis. The aneurysm, decreased branches, congenital hypoplasia, absence, and variant branching of intracranial arteries were observed and evaluated for interobserver agreement and interstudy agreement by kappa analysis. Paired-t-tests for signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were conducted.
RESULTS
Image quality is better for CS-MRA compared with Con-MRA with significance (Z = -3.710 to -2.673, with P < 0.01). The interstudy agreement of lesion and variation of intracranial arteries assessment for each observer was excellent. The SNR and CNR were significantly higher in CS-MRA compared with Con-MRA (P < 0.001). The definition of ECA of CS-MRA was significantly better (Z = -4.9, P < 0.001).
DATA CONCLUSION
CS-MRA showed significantly higher image quality with less blur, comparable image diagnostic performance of intracranial arteries, and better display of ECA than Con-MRA.
LEVEL OF EVIDENCE
3 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:1843-1851.
背景
压缩感知（CS）已被广泛用于提高 MRI 的速度，但在临床实践中需要评估其在三维颅内磁共振血管造影（MRA）中的应用可行性。
目的
与常规三维 MRA（Con-MRA）相比，评估 CS-MRA 的临床可行性。
研究类型
回顾性。
受试者
49 例疑似颅内动脉疾病的连续患者。
磁场强度/序列：3T MRI。使用 CS 算法的三维时间飞跃（TOF）MRA 和常规三维 TOF MRA 扫描。
评估
三位放射科医生（分别具有 4、11 和 12 年神经放射学经验）分别独立评估 CS-MRA 和 Con-MRA 的图像质量、血管病变和颅内动脉变异。
统计学检验
采用 Kendall W 检验评估图像质量和颅内动脉狭窄的观察者间一致性。采用非参数检验（Wilcoxon 检验）比较颈外动脉（ECA）的图像质量和清晰度。采用加权kappa 分析评估颅内动脉狭窄的两种研究间一致性。观察并通过 kappa 分析评估颅内动脉的动脉瘤、分支减少、先天性发育不良、缺失和变异分支的观察者间一致性和两种研究间一致性。采用配对 t 检验进行信噪比（SNR）和对比噪声比（CNR）的比较。
结果
CS-MRA 的图像质量优于 Con-MRA，差异具有统计学意义（Z = -3.710 至-2.673，P < 0.01）。每位观察者对颅内病变和变异的评估的两种研究间一致性均为极好。CS-MRA 的 SNR 和 CNR 明显高于 Con-MRA（P < 0.001）。CS-MRA 对 ECA 的定义明显更好（Z = -4.9，P < 0.001）。
数据结论
CS-MRA 显示出更高的图像质量，具有更少的模糊，与 Con-MRA 相当的颅内动脉成像诊断性能，以及更好的 ECA 显示。
证据水平
3 技术功效分期：2 J. Magn. Reson. Imaging 2019;50:1843-1851.
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