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Men more vulnerable to COVID-19: explained by ACE2 on the X chromosome?男性更易感染新冠病毒:是由X染色体上的血管紧张素转换酶2(ACE2)所导致的吗?
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SARS-CoV-2 Remains Infectious on Refrigerated Deli Food, Meats, and Fresh Produce for up to 21 Days.新型冠状病毒在冷藏的熟食、肉类和新鲜农产品上可保持传染性长达21天。
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BMJ Open Gastroenterol. 2021 Nov;8(1). doi: 10.1136/bmjgast-2021-000738.
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Distinct Regulation of U-ACE2 and P-ACE2 (Urinary and Plasma Angiotensin-Converting Enzyme 2) in a Japanese General Population.在日本普通人群中 U-ACE2 和 P-ACE2(尿和血浆血管紧张素转换酶 2)的不同调节。
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Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor.孟德尔随机化分析提供了吸烟对 ACE2 表达的因果关系,ACE2 是一种假定的 SARS-CoV-2 受体。
Elife. 2021 Jul 6;10:e64188. doi: 10.7554/eLife.64188.
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Correlation of Severity of COVID-19 Disease With Gastrointestinal Manifestations and Liver Injury - A North Brooklyn Community Hospital Experience: A Retrospective Cohort Study.新型冠状病毒肺炎疾病严重程度与胃肠道表现及肝损伤的相关性——北布鲁克林社区医院的经验:一项回顾性队列研究
Cureus. 2021 Apr 18;13(4):e14543. doi: 10.7759/cureus.14543.
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Evaluation of hepatic enzymes activities in COVID-19 patients.评估 COVID-19 患者的肝酶活性。
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Dynamic Changes in Liver Function Tests and Their Correlation with Illness Severity and Mortality in Patients with COVID-19: A Retrospective Cohort Study.动态肝功能变化及其与 COVID-19 患者疾病严重程度和死亡率的相关性:一项回顾性队列研究。
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Liver injury in the era of COVID-19.COVID-19 时代的肝损伤。
World J Gastroenterol. 2021 Feb 7;27(5):377-390. doi: 10.3748/wjg.v27.i5.377.

本文引用的文献

1
Liver injury in COVID-19: management and challenges.新型冠状病毒肺炎中的肝损伤:管理与挑战
Lancet Gastroenterol Hepatol. 2020 May;5(5):428-430. doi: 10.1016/S2468-1253(20)30057-1. Epub 2020 Mar 4.
2
COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission.新型冠状病毒肺炎:胃肠道表现及潜在的粪-口传播
Gastroenterology. 2020 May;158(6):1518-1519. doi: 10.1053/j.gastro.2020.02.054. Epub 2020 Mar 3.
3
Evidence for Gastrointestinal Infection of SARS-CoV-2.新型冠状病毒2019(SARS-CoV-2)胃肠道感染的证据。
Gastroenterology. 2020 May;158(6):1831-1833.e3. doi: 10.1053/j.gastro.2020.02.055. Epub 2020 Mar 3.
4
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.新冠病毒的基因组特征和流行病学:对病毒起源和受体结合的影响。
Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.
5
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.中国武汉 99 例 2019 年新型冠状病毒肺炎患者的流行病学和临床特征:描述性研究。
Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30.
6
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
7
Landscape of X chromosome inactivation across human tissues.人类组织中X染色体失活的全景图。
Nature. 2017 Oct 11;550(7675):244-248. doi: 10.1038/nature24265.
8
Dosage compensation and gene expression on the mammalian X chromosome: one plus one does not always equal two.哺乳动物X染色体上的剂量补偿与基因表达:一加一并不总是等于二。
Chromosome Res. 2009;17(5):637-48. doi: 10.1007/s10577-009-9063-9.

COVID-19 and ACE2 in the Liver and Gastrointestinal Tract: Putative Biological Explanations of Sexual Dimorphism.

作者信息

Pirola Carlos J, Sookoian Silvia

机构信息

University of Buenos Aires, School of Medicine, Institute of Medical Research A Lanari, Ciudad Autónoma de Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), University of Buenos Aires, Institute of Medical Research (IDIM), Department of Molecular Genetics and Biology of Complex Diseases, Ciudad Autónoma de Buenos Aires, Argentina.

University of Buenos Aires, School of Medicine, Institute of Medical Research A Lanari, Ciudad Autónoma de Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), University of Buenos Aires, Institute of Medical Research (IDIM), Department of Clinical and Molecular Hepatology, Ciudad Autónoma de Buenos Aires, Argentina.

出版信息

Gastroenterology. 2020 Oct;159(4):1620-1621. doi: 10.1053/j.gastro.2020.04.050. Epub 2020 Apr 26.

DOI:10.1053/j.gastro.2020.04.050
PMID:32348773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7194954/
Abstract
摘要