Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts.
作者信息
Nicin Luka, Abplanalp Wesley Tyler, Mellentin Hannah, Kattih Badder, Tombor Lukas, John David, Schmitto Jan D, Heineke Jörg, Emrich Fabian, Arsalan Mani, Holubec Tomas, Walther Thomas, Zeiher Andreas M, Dimmeler Stefanie
机构信息
Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Germany.
Department of Medicine, Cardiology, Goethe University Hospital, Frankfurt, Germany.
出版信息
Eur Heart J. 2020 May 14;41(19):1804-1806. doi: 10.1093/eurheartj/ehaa311.
Abstract
摘要
相似文献
1
Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts.人心脏中假定的新型冠状病毒受体血管紧张素转换酶2的细胞类型特异性表达。
Eur Heart J. 2020 May 14;41(19):1804-1806. doi: 10.1093/eurheartj/ehaa311.
2
ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis†.睾丸中 ACE2 受体的表达：在 2019 年冠状病毒病发病机制中的意义。
Biol Reprod. 2020 Aug 21;103(3):449-451. doi: 10.1093/biolre/ioaa080.
3
Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart.单细胞分析 SARS-CoV-2 受体 ACE2 和刺突蛋白在人心脏中对蛋白酶的预激活表达。
Cardiovasc Res. 2020 Aug 1;116(10):1733-1741. doi: 10.1093/cvr/cvaa191.
4
The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.人类心脏中的 ACE2 表达表明了 SARS-CoV-2 感染患者心脏损伤的新潜在机制。
Cardiovasc Res. 2020 May 1;116(6):1097-1100. doi: 10.1093/cvr/cvaa078.
5
Angiotensin Converting Enzyme-2 (ACE2) Receptors, asthma and severe COVID-19 infection risk.血管紧张素转换酶2（ACE2）受体、哮喘与严重新型冠状病毒肺炎感染风险
Eur Ann Allergy Clin Immunol. 2020 Nov;52(6):282-285. doi: 10.23822/EurAnnACI.1764-1489.169. Epub 2020 Nov 3.
6
Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells.雌激素调节分化气道上皮细胞中 SARS-CoV-2 受体 ACE2 的表达。
Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1280-L1281. doi: 10.1152/ajplung.00153.2020. Epub 2020 May 20.
7
Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).新型冠状病毒（SARS-CoV-2）对血管紧张素转换酶2（ACE2）结构识别的遗传变异研究。
J Transl Med. 2020 Aug 24;18(1):321. doi: 10.1186/s12967-020-02486-7.
8
Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19.肾素-血管紧张素抑制对ACE2（血管紧张素转换酶2）和TMPRSS2（跨膜丝氨酸蛋白酶2）表达的影响：对2019冠状病毒病的见解
Hypertension. 2020 Oct;76(4):e29-e30. doi: 10.1161/HYPERTENSIONAHA.120.15782. Epub 2020 Jul 14.
9
Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2.预测血管紧张素转化酶 2（ACE2）作为 SARS-CoV-2 受体的利用能力。
Microbes Infect. 2020 May-Jun;22(4-5):221-225. doi: 10.1016/j.micinf.2020.03.003. Epub 2020 Mar 19.
10
Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.编码血管紧张素转换酶2（ACE2）、跨膜丝氨酸蛋白酶2（TMPRSS2）及介导严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒进入的相关蛋白的基因，在人类心肌细胞中会随着年龄增长而上调。
J Mol Cell Cardiol. 2020 Oct;147:88-91. doi: 10.1016/j.yjmcc.2020.08.009. Epub 2020 Aug 18.
引用本文的文献
1
SARS-CoV-2 Spike Protein and Long COVID-Part 1: Impact of Spike Protein in Pathophysiological Mechanisms of Long COVID Syndrome.严重急性呼吸综合征冠状病毒2刺突蛋白与长期新冠——第1部分：刺突蛋白在长期新冠综合征病理生理机制中的影响
Viruses. 2025 Apr 25;17(5):617. doi: 10.3390/v17050617.
2
Myocarditis and Inflammatory Cardiomyopathy in Dilated Heart Failure.扩张型心力衰竭中的心肌炎与炎症性心肌病
Viruses. 2025 Mar 27;17(4):484. doi: 10.3390/v17040484.
3
Interactions of SARS-CoV-2 with Human Target Cells-A Metabolic View.SARS-CoV-2 与人类靶细胞的相互作用——代谢视角。
Int J Mol Sci. 2024 Sep 16;25(18):9977. doi: 10.3390/ijms25189977.
4
A human cell atlas of the pressure-induced hypertrophic heart.压力诱导性肥厚心脏的人类细胞图谱。
Nat Cardiovasc Res. 2022 Feb;1(2):174-185. doi: 10.1038/s44161-022-00019-7. Epub 2022 Feb 14.
5
The pathological maelstrom of COVID-19 and cardiovascular disease.新冠病毒疾病与心血管疾病的病理漩涡
Nat Cardiovasc Res. 2022 Mar;1(3):200-210. doi: 10.1038/s44161-022-00029-5. Epub 2022 Mar 16.
6
COVID-19 in the Initiation and Progression of Atherosclerosis: Pathophysiology During and Beyond the Acute Phase.新冠病毒感染在动脉粥样硬化的起始和进展中的作用：急性期及之后的病理生理学
JACC Adv. 2024 Jul 17;3(8):101107. doi: 10.1016/j.jacadv.2024.101107. eCollection 2024 Aug.
7
Cardiovascular Comorbidities in COVID-19: Comprehensive Analysis of Key Topics.新冠病毒肺炎中的心血管合并症：关键主题综合分析
Interact J Med Res. 2024 Jul 24;13:e55699. doi: 10.2196/55699.
8
RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis.RNA m5C 甲基化修饰：SARS-CoV-2 相关心肌炎的潜在治疗靶点。
Front Immunol. 2024 Apr 23;15:1380697. doi: 10.3389/fimmu.2024.1380697. eCollection 2024.
9
Acute Myocardial Infarction during the COVID-19 Pandemic: Long-Term Outcomes and Prognosis-A Systematic Review.2019冠状病毒病大流行期间的急性心肌梗死：长期结局与预后——一项系统评价
Life (Basel). 2024 Jan 31;14(2):202. doi: 10.3390/life14020202.
10
Myocardial Angiotensin-Converting Enzyme 2 Protein Expression in Ischemic Heart Failure.心肌血管紧张素转换酶 2 蛋白在缺血性心力衰竭中的表达。
Int J Mol Sci. 2023 Dec 5;24(24):17145. doi: 10.3390/ijms242417145.
本文引用的文献
1
Renin-angiotensin system in human coronavirus pathogenesis.人类冠状病毒发病机制中的肾素-血管紧张素系统。
Future Virol. 2010 Mar;5(2):145-161. doi: 10.2217/fvl.10.4. Epub 2010 Mar 1.
2
Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State.华盛顿州 21 例 COVID-19 危重症患者的特征和结局。
JAMA. 2020 Apr 28;323(16):1612-1614. doi: 10.1001/jama.2020.4326.
3
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
4
SARS-CoV-2: a potential novel etiology of fulminant myocarditis.严重急性呼吸综合征冠状病毒2：暴发性心肌炎的一种潜在新病因。
Herz. 2020 May;45(3):230-232. doi: 10.1007/s00059-020-04909-z.
5
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
6
Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure.肾素-血管紧张素系统的ACE2/血管紧张素1-7轴在心力衰竭中的作用
Circ Res. 2016 Apr 15;118(8):1313-26. doi: 10.1161/CIRCRESAHA.116.307708.
7
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.血管紧张素转换酶2（ACE2）在严重急性呼吸综合征冠状病毒诱导的肺损伤中的关键作用。
Nat Med. 2005 Aug;11(8):875-9. doi: 10.1038/nm1267. Epub 2005 Jul 10.
8
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.SARS冠状病毒功能性受体ACE2蛋白的组织分布。理解SARS发病机制的第一步。
J Pathol. 2004 Jun;203(2):631-7. doi: 10.1002/path.1570.
9
ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors.ACEH/ACE2是一种新型的哺乳动物金属羧肽酶，是对ACE抑制剂不敏感的血管紧张素转换酶的同源物。
Can J Physiol Pharmacol. 2002 Apr;80(4):346-53. doi: 10.1139/y02-021.
Zotero 插件