Zwilling B S, Springer S T, Kaufman D G
J Natl Cancer Inst. 1977 May;58(5):1473-7. doi: 10.1093/jnci/58.5.1473.
Systemic injection of BCG cell walls was evaluated for effects on the development of respiratory tract tumors induced by intratracheal instillation of benzo[a]pyrene plus Fe2O3 in Syrian hamsters. Only 74% of animals developed respiratory tract tumors at the dose level of benzo[a]pyrene used. Treatment with BCG cell walls reduced the incidence of respiratory tract tumors to 50%. A similar effect of treatment with BCG cell walls was found when only malignant tumors of the respiratory tract were considered. Both single and multiple injections of BCG cell walls effectively reduced the incidence of respiratory tract tumors.
评估了全身性注射卡介苗细胞壁对叙利亚仓鼠经气管内滴注苯并[a]芘加三氧化二铁诱导的呼吸道肿瘤发生发展的影响。在所使用的苯并[a]芘剂量水平下，只有74%的动物发生了呼吸道肿瘤。用卡介苗细胞壁治疗可将呼吸道肿瘤的发生率降低至50%。当仅考虑呼吸道恶性肿瘤时，发现卡介苗细胞壁治疗有类似效果。单次和多次注射卡介苗细胞壁均有效降低了呼吸道肿瘤的发生率。
