Terashima H, Yasumoto K, Yanagawa E, Takayama K, Nomoto K, Azuma I, Yamamura Y
Gan. 1981 Jun;72(3):363-9.
The synergistic effect of nonspecific immunotherapy with cell-wall skeleton of BCG on radiotherapy against two syngeneic murine tumors, a methylcholanthrene-induced tumor (MCA) and a spontaneous well-differentiated mammary adenocarcinoma (Br-1), was studied in (+/+) balb/c mice and (nu/nu) mice of BALB/c background. Single irradiation of tumors with a dose of 2000 rad induced complete shrinkage in about 18% of MCA and Br-1 tumors in (+/+) mice. Single irradiation did not induce complete shrinkage of tumors in (nu/nu) mice. When immunotherapy was combined with radiotherapy, the rates of complete shrinkage of MCA and Br-1 tumors increased to 82 and 61%, respectively. In contrast, such a strong synergistic effect was not observed in (nu/nu) mice. Moreover, human lung cancers (two squamous cell carcinomas and two small cell carcinomas) xenotransplanted to nude mice were treated with the combined therapy. The effect was stronger on squamous cell carcinomas than on small cell carcinomas.
在BALB/c背景的(+/+) 品系和(nu/nu) 品系小鼠中，研究了卡介苗细胞壁骨架非特异性免疫疗法与放疗联合对两种同基因小鼠肿瘤（甲基胆蒽诱发瘤（MCA）和自发高分化乳腺腺癌（Br-1））的协同作用。用2000拉德剂量对肿瘤进行单次照射，可使(+/+) 小鼠中约18% 的MCA和Br-1肿瘤完全缩小。单次照射未使(nu/nu) 小鼠的肿瘤完全缩小。当免疫疗法与放疗联合使用时，MCA和Br-1肿瘤的完全缩小率分别增至82% 和61%。相比之下，(nu/nu) 小鼠未观察到如此强的协同作用。此外，对移植到裸鼠体内的人肺癌（两例鳞状细胞癌和两例小细胞癌）进行联合治疗。联合治疗对鳞状细胞癌的效果比对小细胞癌的效果更强。
