Deakin University, 221 Burwood Highway, Burwood, 3125, Australia.
Mech Ageing Dev. 2020 Jun;188:111255. doi: 10.1016/j.mad.2020.111255. Epub 2020 Apr 27.
While elderly patients are at high risk of fatality, research concerning COVID-19 has largely been done on clarifying the clinical features. As such, the present work aims to identify risk factors for mortality in elderly patients with COVID-19. Given that single-centre studies are less likely informative as elderly remains a minority in the total Chinese population, the present study reviewed the clinical data of geriatric COVID-19 patients gathered from different sources in the public domain. Based on the data of 154 individuals from 26 provinces, age remained a key mortality risk factor among geriatric patients of different ages. While dyspnoea and chest pain/discomfort were more commonly seen in deceased patients as they represented severe pneumonia, fever was more prominent in surviving patients. This was likely due to the lower baseline body temperature observed in elderly which translated to a lower maximum temperature of fever. However, lowering the threshold temperature for fever is not recommended in surveillance. Instead, baseline body temperature measured on a regular basis should be used to define the threshold temperature for fever. Against mixed results, more research should be done on identifying comorbidities associated with mortality in geriatric patients.
虽然老年患者的病死率较高,但 COVID-19 的相关研究主要集中在阐明其临床特征上。因此,本研究旨在确定 COVID-19 老年患者死亡的危险因素。鉴于单中心研究的信息量可能较少,因为老年人在全中国人口中仍占少数,本研究回顾了从公共领域不同来源收集的老年 COVID-19 患者的临床数据。基于来自 26 个省的 154 人的数据,年龄仍然是不同年龄老年患者的主要死亡风险因素。虽然呼吸困难和胸痛/不适在死亡患者中更为常见,因为它们代表严重肺炎,但在存活患者中发热更为突出。这可能是由于老年患者的基础体温较低,导致发热的最高体温较低。然而,不建议在监测中降低发热的阈值温度。相反,应使用定期测量的基础体温来定义发热的阈值温度。对于混合结果,应进行更多研究以确定与老年患者死亡相关的合并症。