Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Int J Mol Sci. 2020 Apr 28;21(9):3104. doi: 10.3390/ijms21093104.
On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a pandemic. Taking into consideration the mortality rate of COVID-19, about 5-7%, and the percentage of positive patients admitted to intensive care units being 9-11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. Considering that the COVID-19 infection can generate a mild or highly acute respiratory syndrome with a consequent release of pro-inflammatory cytokines, including IL-6 and TNF-α, a dietary regimen modification in order to improve the levels of adiponectin could be very useful both to prevent the infection and to take care of patients, improving their outcomes.
2019 年 12 月 31 日，世界卫生组织（WHO）收到中国湖北省武汉市不明原因肺炎病例群集的报告。该感染首先在中国传播，然后在世界其他地区传播，3 月 11 日，世界卫生组织宣布 COVID-19 为大流行。考虑到 COVID-19 的死亡率约为 5-7%，以及需要入住重症监护病房的阳性患者比例为 9-11%，应该强制性地考虑并采取一切必要措施来控制 COVID-19 感染。此外，鉴于最近不同医院的证据表明白细胞介素-6 和肿瘤坏死因子-α抑制剂药物可能是 COVID-19 的一种治疗方法，我们旨在强调饮食干预可能有助于预防感染和/或改善治疗期间的结果。鉴于 COVID-19 感染可能会产生轻度或高度急性呼吸系统综合征，从而导致促炎细胞因子（包括白细胞介素-6 和肿瘤坏死因子-α）释放，因此为了提高脂联素水平而改变饮食方案可能对预防感染和照顾患者非常有用，从而改善他们的预后。
